Dartmouth College

To assess the effectiveness of SVD-based denoising on the brain Diffusion Weighted images acquired from a 0.35T ViewRay Magnetic Resonance Linac (MRL) and enhance the image quality while preserving the diffusion information.

Cherenkov Imaging is the method by which the light emitted from a patient’s skin during external beam radiation therapy can be imaged and used to verify dose delivery location. This is accomplished using an intensified CMOS camera time-gated to the linac puls...

Limiting contralateral breast dose (CBD) is an important concern in breast radiotherapy, as prior studies link doses >1Gy to significantly increased secondary cancer risk. Furthermore, complex beam geometry increases low-dose irradiation of healthy tissue whi...

Stark global inequities persist in access to radiological health services, with low- and middle-income countries (LMICs) bearing an increasing cancer burden while facing critical shortages in trained medical physicists and radiation oncologists. Virtual educa...

Interstitial brachytherapy enables highly conformal radiotherapy, but accuracy depends on surgical skill, and few in vivo dosimetry systems exist. Effective monitoring requires not just dose but tracking source position, dwell time, and transit times. We deve...

To develop a reliable batch‑calibration method and dose‑reading protocol for in-vivo scintillation imaging dosimetry during radiation therapy.

Cherenkov imaging is a technique used to observe surface dose deposition during radiation therapy. While proportional to dose, the imaged signal cannot derive absolute dose, due to the attenuation and inhomogeneity of human tissue optics. However, controlled,...

Cherenkov imaging enables real-time visualization of radiation delivery by capturing Cherenkov emission from patient tissue at the beam location. Although this signal can be compared to the expected dose distribution, no established method currently exists to...

FLASH radiotherapy (>40 Gy/s) demonstrates normal tissue sparing while maintaining tumor control, but pulse width variations systematically alter electron beam energy through waveguide loading effects, creating treatment planning system (TPS) challenges. This...

Cherenkov imaging offers real-time visualization and verification of external beam delivery during radiation therapy. However, the relationship between beam parameters and Cherenkov photon yield per unit dose remains underexplored, especially for small-fields...

Cherenkov imaging provides valuable beam delivery information, but fixed treatment camera positions are subject to gantry occlusions and couch rotation artifacts that inhibit imaging for a significant percentage of clinical cases. To overcome these limitation...

FLASH radiotherapy reduces skin damage in vivo from ultra-high dose rate (UHDR) irradiation relative to conventional dose rates (CDR), while preserving tumor tissue damage. The macroscopic FLASH tissue sparing effect has not yet been robustly reproduced in la...

This study was to examine the complimentary damage mechanisms and their potential synergy between conventional/ultrahigh dose rate radiotherapy (CDR/UHDR RT) and photodynamic therapy (PDT). FLASH radiotherapy produces a significant reduction in radiation-indu...

Neck CT protocols often present challenges for objective lesion detectability tasks. We systematically assessed lesion detectability in clinical scans to identify quality gaps and dose utilization inefficiencies.

The FLASH radiotherapy effect is the reduction of radiation-induced normal tissue damage with Ultra-High Dose Rate (UHDR) irradiation, relative to Conventional Dose Rates (CDR), while preserving tumor tissue damage. However, the underlying mechanism remains u...

To evaluate neck CT image quality (IQ) and dose efficiency for lesion assessment across multiple scanners, identifying scanner-level differences and protocol optimization opportunities.

The goal of this project was to investigate whether the FLASH effect can be preserved when an ultra-high-dose-rate (UHDR) delivery is split into multiple beams (2, 4 or 6), all delivered within a time window (5 sec) that was previously shown to preserve the s...

Cherenkov imaging has emerged as a promising technique for real-time dosimetry during external beam radiation therapy (EBRT); however, quantitative conversion of Cherenkov signal to delivered radiation dose remains challenging. The purpose of this study is to...

To evaluate tumor oxygenation response to hyperbaric oxygen therapy using oxygen-enhanced MRI (OE-MRI) and assess whether elevated oxygen partial pressure can convert hypoxic, radiation-resistant tumor regions to a more radiosensitive state.

Ultra-high dose-rate (UHDR) radiotherapy has been reported to reduce normal tissue toxicity compared to conventional dose-rate irradiation (CDR), yet objective, quantitative imaging markers associated with this effect remain limited. This study evaluates whet...

Manual background selection for contrast-to-noise ratio (CNR) calculations in CT image quality assessment is time-consuming, operator-dependent, and introduces >15% measurement variability that compromises reproducibility. Advanced metrics such as Noise Power...

Accurate intraoperative assessment of tissue perfusion is critical for guiding debridement in traumatic and orthopedic injuries. However, existing fluorescence imaging systems are often unsuitable for resource-limited or high-ambient-light environments. This...

To validate and deploy a complete applicator-specific phase space file library for the GMV Radiance treatment planning system, establishing the first clinically ready Monte Carlo-based treatment planning system (TPS) for electron FLASH radiotherapy.

To evaluate the Oxygen Response Index (ORI) as a new oxygen-enhanced MRI (OE-MRI) metric for quantifying tumor radiation therapy efficacy that accounts for tissue oxygen response and tumor size, and to compare its sensitivity for detecting treatment response...