David J. Gladstone, ScD

To assess the effectiveness of SVD-based denoising on the brain Diffusion Weighted images acquired from a 0.35T ViewRay Magnetic Resonance Linac (MRL) and enhance the image quality while preserving the diffusion information.

Limiting contralateral breast dose (CBD) is an important concern in breast radiotherapy, as prior studies link doses >1Gy to significantly increased secondary cancer risk. Furthermore, complex beam geometry increases low-dose irradiation of healthy tissue whi...

Interstitial brachytherapy enables highly conformal radiotherapy, but accuracy depends on surgical skill, and few in vivo dosimetry systems exist. Effective monitoring requires not just dose but tracking source position, dwell time, and transit times. We deve...

To develop a reliable batch‑calibration method and dose‑reading protocol for in-vivo scintillation imaging dosimetry during radiation therapy.

FLASH radiotherapy (>40 Gy/s) demonstrates normal tissue sparing while maintaining tumor control, but pulse width variations systematically alter electron beam energy through waveguide loading effects, creating treatment planning system (TPS) challenges. This...

Cherenkov imaging provides valuable beam delivery information, but fixed treatment camera positions are subject to gantry occlusions and couch rotation artifacts that inhibit imaging for a significant percentage of clinical cases. To overcome these limitation...

This study was to examine the complimentary damage mechanisms and their potential synergy between conventional/ultrahigh dose rate radiotherapy (CDR/UHDR RT) and photodynamic therapy (PDT). FLASH radiotherapy produces a significant reduction in radiation-indu...

Ultra-high dose-rate (UHDR) radiotherapy has been reported to reduce normal tissue toxicity compared to conventional dose-rate irradiation (CDR), yet objective, quantitative imaging markers associated with this effect remain limited. This study evaluates whet...

To validate and deploy a complete applicator-specific phase space file library for the GMV Radiance treatment planning system, establishing the first clinically ready Monte Carlo-based treatment planning system (TPS) for electron FLASH radiotherapy.