Author profile
University of Wisconsin - Madison
Cherenkov Imaging is the method by which the light emitted from a patient’s skin during external beam radiation therapy can be imaged and used to verify dose delivery location. This is accomplished using an intensified CMOS camera time-gated to the linac puls...
Cherenkov imaging enables non-invasive, real-time visualization of superficial dose during radiation therapy. In TSET using the Stanford standing technique, dose uniformity is highly sensitive to daily patient positioning. This study aims to experimentally de...
Cherenkov imaging is a technique used to observe surface dose deposition during radiation therapy. While proportional to dose, the imaged signal cannot derive absolute dose, due to the attenuation and inhomogeneity of human tissue optics. However, controlled,...
Cherenkov imaging enables real-time visualization of radiation delivery by capturing Cherenkov emission from patient tissue at the beam location. Although this signal can be compared to the expected dose distribution, no established method currently exists to...
Cherenkov imaging offers real-time visualization and verification of external beam delivery during radiation therapy. However, the relationship between beam parameters and Cherenkov photon yield per unit dose remains underexplored, especially for small-fields...
Cherenkov imaging provides valuable beam delivery information, but fixed treatment camera positions are subject to gantry occlusions and couch rotation artifacts that inhibit imaging for a significant percentage of clinical cases. To overcome these limitation...
FLASH radiotherapy reduces skin damage in vivo from ultra-high dose rate (UHDR) irradiation relative to conventional dose rates (CDR), while preserving tumor tissue damage. The macroscopic FLASH tissue sparing effect has not yet been robustly reproduced in la...
This study was to examine the complimentary damage mechanisms and their potential synergy between conventional/ultrahigh dose rate radiotherapy (CDR/UHDR RT) and photodynamic therapy (PDT). FLASH radiotherapy produces a significant reduction in radiation-indu...
The FLASH radiotherapy effect is the reduction of radiation-induced normal tissue damage with Ultra-High Dose Rate (UHDR) irradiation, relative to Conventional Dose Rates (CDR), while preserving tumor tissue damage. However, the underlying mechanism remains u...
The goal of this project was to investigate whether the FLASH effect can be preserved when an ultra-high-dose-rate (UHDR) delivery is split into multiple beams (2, 4 or 6), all delivered within a time window (5 sec) that was previously shown to preserve the s...
Cherenkov imaging has emerged as a promising technique for real-time dosimetry during external beam radiation therapy (EBRT); however, quantitative conversion of Cherenkov signal to delivered radiation dose remains challenging. The purpose of this study is to...
Therapy Physics
Ultra-high dose-rate (UHDR) radiotherapy has been reported to reduce normal tissue toxicity compared to conventional dose-rate irradiation (CDR), yet objective, quantitative imaging markers associated with this effect remain limited. This study evaluates whet...