The University of Alabama at Birmingham

To investigate the effect of bolus–surface air gap on surface dose calculation for a clinical 6 MV photon beam.

Accelerated partial breast irradiation (APBI) combined with online adaptive radiotherapy (OART) offers precise treatment of early-stage breast cancer, but inter-observer variability (IOV) in target delineation must be accounted for to maintain treatment quali...

Open-ended survey responses are extremely valuable since participants voluntarily share insights that they feel are necessary to express. The purpose of this study is to accurately reflect members’ perception of the AAPM climate, through analysis of open-ende...

Treatment planning system (TPS) beam modelling is identified as the largest cause of independent dosimetry audit failure. This study aims to develop and validate a universal beam model (UBM) specific to single-iso multi-target (SIMT) stereotactic radiosurgery...

Automated radiotherapy treatment planning pipelines can reduce planning time and improve standardization, but clinical adoption is often limited by the time and specialized automation expertise required to define, configure, and maintain these pipelines. We d...

We present advancements of single-molecule biodosimetry to measure radiation-induced DNA damage from α-emitting 225Ac. These results will be compared to β-emitting radionuclides to assess relative biological effectiveness (RBE) for radionuclide therapies.

MLC backlash is a linac failure mode that results in MLC positional error that has been demonstrated to not be prevented by the linac’s internal safety systems [1]. This study aims to inform on the clinical significance of MLC positional error due to MLC back...

This study investigates correction factors commonly used in calculating peak skin dose (PSD) from IR procedures. Specifically, it examines 1- effect of patient-induced compression of the table/pad on transmission factors and, 2- the contribution of scatter fr...

Small metallic objects such as titanium and tantalum surgical clips are frequently present in clinical treatment planning images. Because these objects produce streak artifacts in planning CT images and may lie within the beam path, there is concern that they...

This work focuses on implementing a GPU-accelerated multi-criteria optimization (MCO) framework for HDR brachytherapy, including advanced applicators such as Direction-Modulated Brachytherapy (DMBT), and developing a graphical user interface (GUI) to enable c...

CT-guided adaptive radiotherapy (CTgART) introduces substantial workflow complexity and resource demands. While clinical experience is expected to improve efficiency, the magnitude and structure of adaptive learning have not been well quantified using objecti...

CT-guided online adaptive radiotherapy(CTgART) introduces substantial per-patient variability in session duration, complicating prospective scheduling. This study evaluates whether system-reported reference plan calculation metrics, specifically reference pla...

Vertical patient off-centering is a common positioning error known to alter automatic exposure control (AEC) behavior and increase variability in both radiation output and image quality. The purpose of this study is to systematically quantify the impact of ve...

Accurate quantitative magnetic resonance spectroscopy (MRS) is essential for metabolic imaging, yet conventional Fourier-based analysis fails when spectra exhibit extreme dynamic range, as commonly encountered in hyperpolarized 13C MRS. Dominant injected subs...

This study aims to develop and evaluate a framework to generate fully automated prostate HDR brachytherapy plans using predicted dose from deep learning model, reducing planner dependence and planning time.

Online adaptive radiotherapy (oART) mitigates interfraction motion and enables potential reduction of planning target volume (PTV) margins relative to standard-of-care approaches. This study evaluates the robustness of 2 mm PTV margins in a prospective stereo...

Radiotherapy planning requires frequent interaction with complex clinical software, creating inefficiency and opportunities for error. Current automation pipelines depend on scripting, large datasets, or vendor-specific APIs. Here, we assess whether a one-sho...

Clinical medical software is often deployed through streamed environments such as Citrix, where conventional automation methods fail due to the lack of native operating system controls and application programming interfaces. This work presents a visual-langua...

We developed a unified, fully automated, and open-source VMAT planning framework for three complex modalities: VMAT total body irradiation (VMAT-TBI), craniospinal irradiation (VMAT-CSI), and total marrow and lymphoid irradiation (VMAT-TMLI). The goal was to...

Radiotherapy plan quality education is limited by case availability, frequent clinical interruptions, and difficulty aligning schedules. These barriers leave residents underprepared to identify and correct suboptimal plans, potentially compromising future out...

Therapy Physics

The Liberty Vision Y-90 ophthalmic applicator (LV-90) is an FDA approved HDR source for episcleral brachytherapy to treat ocular tumors and benign growths. It is an attractive option for patients because it does not require episcleral sutures, muscle relocati...

With advances in Targeted Alpha Therapy (TAT) preclinical and clinical research, the importance for accurate and traceable dosimetry with sub-organ resolution becomes critical. Current limitations in verifying imaging resolution and activity quantification hi...

Radiation therapy treatment planning systems (TPS) rely on multiple DICOM DIMSE connections to exchange imaging, structure, plan, and dose data with upstream and downstream clinical systems. While standards exist for secure DICOM communication, there remains...

Therapy Physics

For single-isocenter multi-target (SIMT) stereotactic radiosurgery (SRS), benchmarking, auditing and inter-institutional standardization of dose delivery remains challenging as it requires specialized equipment and expertise. Electronic portal imaging devices...

Numerous studies have quantified target baseline positional drift rates across anatomic sites; however, these investigations are often limited by surrogate localization methods (e.g., surface-guidance), single-site analyses, or limited datasets. Here, we leve...