Medical College of Wisconsin

Single fraction palliative radiotherapy is resource intensive, often requiring several hours to prepare and multiple table transfers per patient. Helical tomotherapy systems can acquire large field-of-view ClearRT kVCT images suitable for treatment planning....

MR-only radiotherapy (RT) planning faces workflow challenges that limits its use in routine practice. Currently, clinics rely on manual contouring and/or deep learning based automatic segmentation (DLAS) trained using clinical-specific MRI sequences. The form...

Urgent clinical electron radiotherapy for postoperative treatments (e.g., keloid) is often performed without CT-based planning. In a large hospital network with multiple treatment locations, variability in electron data and workflows across treatment machines...

Accurate precise planning and delivery of linac-based stereotactic radiosurgery (SRS) can be technically challenging and stressful. Thus, it is important to develop a streamlined clinical workflow to increase efficiency, accuracy and precision of the treatment

Understanding of medical physics is essential for safe and effective radiation oncology practice. This study evaluates current instructional practices for physics education in radiation oncology physician residency programs following the release of the AAPM/A...

MRI-guided laser interstitial thermal therapy (LITT) provides minimally invasive option for treating recurrent brain tumors. No accurate and rapid treatment planning methods currently exist for quantitatively predicting patient specific thermal dose. Here we...

To introduce a conditional Wavelet Diffusion framework incorporating depth-wise convolution for efficient high-resolution 3D medical image synthesis, and to evaluate its performance on MRI cross-modality translation and CT texture generation for realistic dig...

The Elekta Comprehensive Motion Management (CMM) system enables real-time monitoring of tumor motion with high temporal resolution and accuracy. Using histogram analysis of tumor positional oscillations, we propose a patient-specific gating strategy to maximi...

This study aimed to evaluate Adapt LTE, a retrospective evaluation tool by Accuray to compare past helical treatment plans against original therapy goals.

Accurate deformable image registration (DIR) between magnetic resonance imaging (MRI) and computed tomography (CT) remains a significant challenge in gynecologic brachytherapy, particularly between images acquired with and without a brachytherapy applicator i...

Gynecological high dose rate (HDR) brachytherapy patients receiving treatment for cervical cancers are under anesthesia during planning and treatment. Minimizing planning time without compromising safety and effectiveness would improve patient care, improve p...

High-dose-rate interstitial brachytherapy (IB) is an effective treatment for gynecologic (GYN) malignancies but requires precise catheter placement, which can be challenging during transperineal and free-hand insertions. Augmented reality (AR) driven MR-guide...

Dose-volume constraints for organs at risk (OARs) in stereotactic body radiation therapy (SBRT) for thoracic cancer patients have been well established through multiple prospective clinical trials. However, during equivalent dose in 2 Gy fractions (EQD2) summ...

Universal CT number to mass density (CTN-to-MD) curves in large hospital networks with multiple CT simulators and treatment planning systems reduces the potential for error during photon treatment planning. The goal of this study was to evaluate the effects o...

Synthetic CT (sCT) derived from CBCT images show potential to facilitate online adaptive radiotherapy (oART) by enhancing CBCT image quality. Compared to sCT from a 2D deep-learning (DL) model that can result in through-plane streak artifacts, we evaluate a 2...

Pulmonary fluid changes often necessitate treatment replanning; however, associated mass variations compromise deformable dose accumulation (DDA) and complicate its evaluation. Accurate estimation of cumulative dose and its associated uncertainty is therefore...

Proton pencil beam scanning (PBS) spot profiles are traditionally modeled using orthogonal X and Y profiles. In-air measurements may exhibit asymmetry and rotation. This study evaluates whether rotation-aware elliptical spot characterization produces meaningf...

This study aims to compare plan quality between helical photon and IMPT proton delivery platforms across multiple disease sites to evaluate whether helical plans could provide an effective and rapid backup to proton therapy.

To evaluate the use of image-guided radiation therapy (IGRT) tools and physics plan review practice in low- and middle-income countries (LMICs). By identifying barriers to IGRT implementation, this study aims to inform best practices that optimize treatment p...

In clinics operating multiple helical delivery systems, treatment plan transfer between machines is frequently desired to improve scheduling flexibility. Despite beam matching, vendor guidance commonly recommends repeating full patient-specific IMRT QA after...

The CT CAP W/O CONT protocol (Computed tomography for chest, abdomen, and pelvis without contrast) is routinely scanned in patients for assessment of systemic disease, oncologic surveillance and staging. Traditionally, this protocol is performed with a two-pa...

Daily cone-beam CT (CBCT) is widely used in adaptive proton therapy; however, scatter artifacts can degrade image quality and introduce proton dose calculation inaccuracies. We developed a region-of-interest (ROI)–guided Swin-Transformer deep learning (DL) ne...

Therapy Physics

Single-dose, low flip angle (LFA) dynamic susceptibility contrast MRI (DSC-MRI) has been adopted as a consensus protocol for brain tumor perfusion imaging. However, a lower flip angle could reduce contrast-to-noise ratio (CNR) which may compromise voxel-wise...

We previously reported feasibility of RayStation for Unity MR-Linac planning with various advantages. However, the lack of automated objective-weight optimization can limit the effectiveness of daily planning with large anatomical changes. This work investiga...

Dose mapping is particularly challenging in reirradiation patients after neoadjuvant radiotherapy and surgery as a result of substantial anatomical rearrangement, often limiting clinical practice to point-summation approaches that lack spatial localization. W...

To demonstrate a multi-modal magnetomechanical imaging platform for fetal cardiac evaluation that integrates simultaneous fetal magnetocardiography (fMCG) and fetal echocardiography (fEcho). This is achieved by developing a methodology that, for the first tim...