No, I Know the Real Mechanism of the Flash Effect - A Mini-Debate
Description
The mechanism responsible for the “FLASH-effect”, the observed healthy tissue sparing without impacting tumor control when irradiating at ultra-high dose-rates is still highly debated. After a decade of research, several hypotheses emerged, yet, none can explain all experimental data. It is time to pitch experts in the field against each other in an educational mini-debate, shedding light on the pros and cons of each hypothesis, highlighting data that is missing and the gaps in our knowledge. Each speaker will get to present their arguments in three rounds. The focus of the three rounds will be: 1 – Defend the hypothesis, showing supportive data and highlighting the strengths 2 – Explain why the other hypotheses are not correct or sufficient 3 – Discuss the clinical and translational implications if the hypothesis is correct. The discussants will each get to defend one of the following hypotheses: 1)