Yuting Lin, PhD

Monte Carlo (MC) methods are widely used for proton therapy dose calculation due to their high physical accuracy, but their stochastic nature results in statistical noise and long computation times, particularly for high-resolution dose calculations and itera...

This study aims to investigate the develop ultra-high-dose-rate (UHDR) proton FLASH spatially-fractionated-radiation-therapy (FLASH-SFRT) irradiations on a compact proton synchrocyclotron for preclinical experiments.

Safe and effective reirradiation depends on accurate cumulative dose assessment and consistent reporting of prior treatments. Current practices for dose accumulation vary widely across Canadian institutions, leading to inconsistencies in cumulative organ-at-r...

Proton LATTICE (pLATTICE) therapy delivers spatially heterogeneous dose distributions with high‑dose peaks embedded within low‑dose valleys. Conventional pLATTICE planning typically uses multiple beam angles per peak, making peak localization vulnerable to pr...

Lattice radiotherapy (LATTICE) is a spatially fractionated technique that delivers high doses to discrete peak regions within the target while maintaining lower doses in surrounding valley regions, yielding a high peak-to-valley dose ratio (PVDR). Conventiona...

Lattice radiotherapy (LRT) is a spatially fractionated radiation technique that creates three-dimensional arrays of high-dose vertices within tumor volumes. Current LRT implementations face geometric constraints in small and medium-sized tumors, primarily due...

Lattice stereotactic body radiation therapy (Lattice SBRT) delivers spatially fractionated high-dose vertices embedded within a lower-dose tumor base, producing steep dose gradients potentially sensitive to interfractional anatomical change. This study evalua...

Personalized Ultra-Fractionated Stereotactic Adaptive Radiotherapy (PULSAR) delivers high-dose radiation pulses separated by intervals of several weeks, enabling tumor response–guided adaptation, reduced toxicity, and potential synergy with immunotherapy. How...

Minibeam radiation therapy (MBRT) is a spatially fractionated technique that produces millimeter-scale dose heterogeneity with promising normal tissue–sparing effects. Implemented using metallic collimators mounted on the accessory tray, MBRT can be delivered...

Proton minibeam radiation therapy (pMBRT) reduces normal tissue toxicity while preserving tumor control through spatial dose fractionation. However, multi-slit collimators (MSCs) substantially increase monitor unit requirements and delivery times, limiting cl...

The mechanism responsible for the “FLASH-effect”, the observed healthy tissue sparing without impacting tumor control when irradiating at ultra-high dose-rates is still highly debated. After a decade of research, several hypotheses emerged, yet, none can expl...

Spatially fractionated proton therapy enables spatial dose modulation that may improve normal tissue tolerance; however, generating controlled peak–valley dose patterns while maintaining adequate target coverage remains challenging. In particular, achieving c...

This scientific panel discussion will include 3 NIH-funded researchers investigating predictive models that are in the process of being validated prior to their use in clinical trials. Three medical physicists will describe their models and validation process...

On-board kV imaging systems on proton therapy machines predominantly rely on scintillator-based energy-integrating detectors (EIDs) for planar imaging and cone-beam CT (CBCT). However, EID-based CBCT is limited by suboptimal image quality and insufficient qua...

Therapy Physics

Automation has become integral to modern radiation oncology—including image registration, contouring, planning, adaptive workflows, and quality assurance (QA). While these systems improve efficiency, they also introduce new vulnerabilities when automation fai...

In this work, we experimentally commissioned proton spatially-fractionated-radiotherapy (pSFRT) clinical treatments on a compact proton synchrocyclotron. This involved an initial assessment of proton small-field dosimetry calculation accuracies with comprehen...

Radiation oncology is undergoing a transformative shift with the emergence of novel modalities that challenge traditional paradigms of dose delivery and biological response. This symposium will explore three cutting-edge approaches—Spatially Fractionated Radi...

Proton minibeam radiation therapy (pMBRT) employs spatially fractionated dose distributions to improve the therapeutic index by reducing normal tissue toxicity. A key component of pMBRT is multi-slit collimator (MSC), which shapes the beam into narrow, spatia...