Author profile
Massachusetts General Hospital and Harvard Medical School
Preclinical studies combining radiation with gadolinium-based AGuIX nanoparticles show potent radiosensitization effect. However, physics simulations to date show a lack of macroscopic dose enhancement. We address this by shifting from absorbed dose (D) to mi...
To quantify the impact of proton dose calculation methodology, including nuclear halo contributions, on secondary cancer risk for near-field organs following proton craniospinal irradiation.
Ensuring precise delivery of radiotherapy is paramount, especially in high dose rate settings where small deviations can create large, unplanned doses, jeopardizing patient safety and treatment outcome. Current dosimetry and QA methods operate on signals anal...
The NCI Pediatric Proton and Photon Therapy Comparison Cohort aims to compare the risk of second malignancies in patients treated with proton versus photon radiotherapy. Using Monte Carlo (MC) simulations, normal tissue dose estimates were retrospectively cal...
Therapy Physics
Iatrogenic cognitive deficits are a major concern in neuro-radiotherapy, especially in pediatric cases. Compared to X-ray treatment modalities, proton and ion beam therapies show improved sparing of cognitive functions, for which optimal neuronal dendritic br...
The mechanism responsible for the “FLASH-effect”, the observed healthy tissue sparing without impacting tumor control when irradiating at ultra-high dose-rates is still highly debated. After a decade of research, several hypotheses emerged, yet, none can expl...
Diagnostic and Interventional Radiology Physics