Debate: Multi-Time-Point vs Single-Time-Point Dosimetry
Description
This session will present a structured debate on single versus multiple timepoint dosimetry in radiopharmaceutical therapy, highlighting both technical and clinical perspectives. A speaker from the nuclear medicine/imaging side will discuss the benefits and rationale of multiple timepoint acquisition, emphasizing kinetic accuracy, image quantification considerations, and their impact on absorbed dose estimates. The session will cover how different temporal sampling strategies influence the reliability of activity–time curves and the interpretation of dose–response data. The second talk, bringing a radiation oncology and dosimetry-focused view, will address implementation realities, uncertainty management, and QA considerations associated with both single and multiple timepoint methods. The discussion will center on how these approaches translate into clinical workflows, resource use, and potential effects on decision-making and trial design.