All conference submissions

The Mayo Clinic Florida microdosimetric kinetic model (MCF MKM) provides highly accurate relative biological effectiveness (RBE) calculations for carbon ion radiation therapy (CIRT), but its clinical use is limited by extreme mem...

Stereotactic body radiotherapy (SBRT) plays a central role in the management of early-stage and oligometastatic lung cancer. Over recent years, there has been significant interest in automating treatment planning through the deve...

CBCT is essential for daily anatomy assessment in ART, but artifacts and unstable HUs impair dose accuracy, and existing corrections or sCT add uncertainties. This study introduces a unified framework for direct CBCT dose correct...

We present advancements of single-molecule biodosimetry to measure radiation-induced DNA damage from α-emitting 225Ac. These results will be compared to β-emitting radionuclides to assess relative biological effectiveness (RBE) f...

This study aims to evaluate the planning feasibility and dosimetric performance of a discrete-step proton arc (DSPAT) using a standardized head phantom on an IBA Proteus Plus proton therapy system.

Longitudinal deformable registration is crucial for accurate dose accumulation in magnetic resonance guided adaptive radiotherapy (MRgART). This is particularly difficult for pancreatic cancer, with both substantial inter-fractio...

A CT-simulation approach has been developed which images free breathing patients with lung tumors by generating a motion model that is a function of breathing amplitude and rate (5DCT). Of the >300 patients simulated with 5DCT, 1...

Radiation-induced lung injury, characterized by chronic inflammation and fibrosis, limits the dose we can give in lung cancer radiotherapy. Drugs that block this response have been shown to protect normal lung tissues from radiat...

Rectal gas variability introduces density heterogeneities that may compromise dose robustness in rectal proton therapy and affect bladder and bowel dosimetry. This study evaluates the impact of rectal gas variability on target co...

Use of task-based detectability index (d’) enables comparison of phantom-patient image quality in a clinically meaningful and vendor-agnostic manner, incorporating resolution details and noise characteristics beyond CNR. Measurin...

Dose–volume metrics alone incompletely explains mandibular osteoradionecrosis (ORN) following proton therapy. LET-based aggregate approaches such as dose–LET volume histograms (DLVH) implicitly assume uniform LET contribution acr...

Pencil beam scanning (PBS) proton therapy provides highly conformal dose distributions that are increasingly leveraged for postmastectomy radiation therapy (PMRT) to reduce cardiopulmonary exposure. However, implant-based reconst...

Proton prostate SBRT is characterized by steep dose gradients and elevated linear energy transfer (LET) near the end of range, which may contribute to genitourinary (GU) toxicity. Prior work suggests that bladder neck (trigone) d...

Conventional LDR brachytherapy seeds rely on internal radiopaque markers that were incorporated to enhance radiographic visibility. With widespread adoption of modern 3D imaging modalities such as CT, the marker presence degrades...

To quantify organ-at-risk (OAR) sparing achievable using a hybrid approach combining conventional image-guided radiotherapy (IGRT) with a CT-guided online adaptive radiotherapy (CT-ART) cone-down boost for pelvic malignancies.

Implanted spacers can improve rectal sparing in prostate radiation therapy. Several systems are commercially available, including hydrogel and liquid-filled balloon variants. Here, we perform an initial dosimetric evaluation of r...

Accurate breath-hold reproducibility is critical in left-sided breast irradiation to reduce cardiac and lung dose, and differences in motion management techniques may influence delivered dose accuracy. The purpose of this study i...

Brachytherapy (BT) remains the standard modality for dose escalation in cervical cancer boost targets, with well-established high-dose-rate (HDR) EQD2 constraints based on HR-CTV D90 and organ-at-risk (OAR) D2cc metrics. However,...

High-dose-rate interstitial brachytherapy (HDR-IBT) is an essential component of curative treatment for locally advanced cervical cancer (LACC), but it is invasive and resource-intensive. Alternative boost techniques are needed w...

This study compares the dosimetric treatment plan quality of Lattice Radiation Therapy plans generated on Varian C-arm LINACs (TrueBeam and Edge) and Radixact TomoTherapy.

Dual energy CT (DECT) has been demonstrated to more accurately predict relative stopping power (RSP) for proton therapy planning over the conventional method of HU-RSP conversion using single energy CT (SECT). In this study, trea...

Total body irradiation (TBI) is a key component of myeloablative conditioning before hematopoietic stem cell transplantation. Modern TBI techniques are increasingly moving towards multi-isocentric VMAT approaches to improve dose...

HDR gynecologic brachytherapy can involve creating a new plan for each fraction of treatment or delivering a single plan for both fractions of an implant. This work retrospectively analyzes the differences in EQD2 doses to the CT...

Total Skin Electron Therapy (TSET) treats cutaneous lymphomas and other superficial malignancies by delivering a uniform electron dose over the skin. Partial-body rotational TSET requires shielding of critical structures, but con...