University of Washington and Fred Hutchinson Cancer Center

High linear energy transfer (LET) IMNT faces practical delivery constraints: low output rates (~55 MU/min), manual gantry and couch rotations (~3-5 min/field), and mandatory wait times (~1-2 min/field) for neutron activation concerns. Our standard-of-care (SO...

Uncertainty-aware multimodal biomarker-guided treatment response prediction in metastatic NSCLC remains a critical unmet need to support robust therapy selection and adaptation over time. We developed a multimodal framework integrating FDG-PET, T-cell recepto...

Therapy Physics

Early body composition (BC) loss after chemotherapy associates with poor outcomes in PDAC, but its implications for treatment strategy remain unclear. Radiotherapy (RT) is sometimes considered after 6 months of chemotherapy for patients with unresectable dise...

To determine optimal scan and reconstruction parameters of a novel dual-energy CT (DECT) scanner for radiotherapy treatment planning across different patient scenarios.

Multiscale treatment response prediction in advanced NSCLC enables spatially informed dose painting, yet prediction point estimates alone do not convey the uncertainty required for adaptive therapy decision support. We developed a multiscale conformal predict...

Patients receiving radiotherapy (RT) for liver cancer have limited liver function reserves, which increases risk of radiation-induced liver injury, but tools to evaluate functional response post-RT are lacking. We modeled liver function changes on 99mTc sulfu...

Therapy Physics

Stereotactic arrhythmia radioablation (STAR), a non-invasive treatment option for refractory ventricular tachycardia (VT), faces challenges from combined respiratory and cardiac motion, necessitating large target margins or motion mitigation. Respiratory gati...

This scientific panel discussion will include 3 NIH-funded researchers investigating predictive models that are in the process of being validated prior to their use in clinical trials. Three medical physicists will describe their models and validation process...