Yale University School of Medicine

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In image-guided radiation therapy (IGRT), patient positioning is typically estimated by rigid registration between cone-beam CT (CBCT)–derived digitally reconstructed radiographs (DRRs) and treatment kV X-ray images acquired at the same gantry angle. However,...

The RefleXion linear accelerator utilizes a 6 MV FFF beam with a binary multi-leaf collimator and a pair of Y- jaws with clinical openings of 1 cm and 2 cm. The machine is equipped with a 16-slice on-board fan-beam CT and an on- board PET detector system. For...

To investigate the feasibility of three-dimensional fiducial localization using small-angle kV image pairs from adjacent projections as a time-efficient alternative to conventional orthogonal imaging, and to determine the minimum gantry angle separation.

Therapy Physics

Understanding of medical physics is essential for safe and effective radiation oncology practice. This study evaluates current instructional practices for physics education in radiation oncology physician residency programs following the release of the AAPM/A...

Congenital heart defects are the most common type of birth defect, and their management often requires lifelong medical care. Interventional cardiology procedures frequently rely on imaging modalities that use ionizing radiation, potentially exposing pediatri...

To commission Standard Imaging Exradin W1 scintillator detector (W1) on RefleXIon PET-Linac system for small-field dosimetry in both image-guided radiotherapy (IGRT) and biology-guided radiotherapy (BgRT).

Simulation-free radiation therapy (SFRT) is an emerging paradigm which expedites palliative radiation by omitting a dedicated simulation computed tomography (CT) scan. This study quantifies dosimetric uncertainties associated with SFRT for three different pla...

Radiation pneumonitis (RP) remains a clinically significant dose-limiting toxicity in thoracic radiotherapy. Accurate RP prediction is challenging due to its multifactorial etiology and complex interactions among contributing factors. Although multimodal data...

This study aims to quantitatively evaluate intrafraction target motion through post-treatment analysis based on offset-dependent three-dimensional reconstruction of on-treatment kV images.

The next-generation PET-based SCINTIX® Biology-guided radiotherapy (BgRT) X2 platform incorporates a four-time PET widened field of view (WFOV) and an anchor-point-tracking delivery algorithm (currently in development). These advancements are intended to impr...

Biology-guided radiotherapy (BGRT) for non-small cell lung cancer (NSCLC) produces high-frequency per-fraction imaging and delivered dose data that captures evolving normal tissue biology throughout treatment. Current toxicity prediction relies on static, pop...

Burnout remains a critical issue across medical fields, including medical physics. Characterized by emotional exhaustion, depersonalization, and a reduced sense of personal accomplishment, burnout impacts both personal well-being and patient safety. A 2019 JA...

This study aims to quantitatively evaluate the three-dimensional positional fidelity of implanted fiducial markers in deep learning-based sparse-view reconstruction from on-treatment kV images acquired during prostate stereotactic body radiotherapy (SBRT).

Diagnostic and Interventional Radiology Physics