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Rank #292 · 3 unique linked submissions.
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Mechanistic models can help us understand why hadrons kill cells more effectively than photons. We used ChronoRepair, an agent-based model that tracks individual double-strand breaks (DSB) through detection, repair, and cell-fate decisions, to identify which...
Preclinical studies combining radiation with gadolinium-based AGuIX nanoparticles show potent radiosensitization effect. However, physics simulations to date show a lack of macroscopic dose enhancement. We address this by shifting from absorbed dose (D) to mi...
To evaluate the feasibility of using a 4.2 MV imaging beam for simultaneous guidance and biologically enhanced delivery of preoperative stereotactic ablative radiotherapy (SABR) to intact breast tumors loaded with gold nanoparticles (AuNPs), and evaluate the...