Author profile
Department of Radiation Oncology, Dana Farber Cancer Institute and Mass General Brigham, Harvard Medical School
Mechanistic models can help us understand why hadrons kill cells more effectively than photons. We used ChronoRepair, an agent-based model that tracks individual double-strand breaks (DSB) through detection, repair, and cell-fate decisions, to identify which...
Preclinical studies combining radiation with gadolinium-based AGuIX nanoparticles show potent radiosensitization effect. However, physics simulations to date show a lack of macroscopic dose enhancement. We address this by shifting from absorbed dose (D) to mi...
To evaluate the feasibility of using a 4.2 MV imaging beam for simultaneous guidance and biologically enhanced delivery of preoperative stereotactic ablative radiotherapy (SABR) to intact breast tumors loaded with gold nanoparticles (AuNPs), and evaluate the...