National Institutes for Quantum Science and Technology (QST)

Neon ions (²⁰Ne) offer substantially higher clinically achievable dose-averaged linear energy transfer (LETd) escalation in the target compared to protons or carbon ions. LETd escalation has the potential to enhance biological effectiveness against radio-resi...

To establish the treatment planning protocol and evaluate the biological rationale for the world’s first dose-averaged LET (LETd)-optimized multi-ion therapy program for head and neck cancers. This study characterizes the plan robustness and potential therape...

LETd escalation within the tumor shows promise in enhancing biological effectiveness in carbon-ion radiotherapy to combat radio-resistant factors such as tumor hypoxia. In this work, in silico investigations and experimental validations were performed to asse...