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Author profile
Takamitsu Masuda, PhD
Department of Accelerator and Medical Physics, National Institutes for Quantum Science and Technology (QST)
LETd Escalation Using Scanned Neon (20Ne) Ion Therapy for Radioresistant Tumors
Neon ions (²⁰Ne) offer substantially higher clinically achievable dose-averaged linear energy transfer (LETd) escalation in the target compared to protons or carbon ions. LETd escalation has the potential to enhance biological effectiveness against radio-resi...
Poster Program · Therapy Physics
The First Multi-Ion Therapy for Head and Neck Cancers: Planning Protocol, Plan Robustness, and Biological Rationale for a Phase I Clinical Trial
To establish the treatment planning protocol and evaluate the biological rationale for the world’s first dose-averaged LET (LETd)-optimized multi-ion therapy program for head and neck cancers. This study characterizes the plan robustness and potential therape...
Proffered Program · Therapy Physics
Robust Optimization and Experimental Validation of LETd‑Escalated Carbon‑Ion Arc Therapy for Head and Neck Cancer
LETd escalation within the tumor shows promise in enhancing biological effectiveness in carbon-ion radiotherapy to combat radio-resistant factors such as tumor hypoxia. In this work, in silico investigations and experimental validations were performed to asse...
Proffered Program · Therapy Physics