Western University

Functional lung avoidance radiation therapy (FLART) uses pre-treatment ventilation imaging to spare high-functioning lung from radiation. The FLAIR trial, the first randomized controlled trial of this approach, found no quality-of-life benefit in ex-smokers w...

To develop an approach for deriving myocardial perfusion maps directly from multi-phase coronary CT angiography (CTA), eliminating the need for dedicated cardiac CT perfusion (CTP) protocols.

This study develops a CT perfusion (CTP) method for simultaneous lung ventilation and perfusion imaging, overcoming limitations of conventional V/Q scans such as temporal mismatch, low resolution, procedural inefficiency, and qualitative-only evaluation.

To accurately calculate the cellular-level absorbed dose for 225Ac, 177Lu, and 161Tb radioligand therapy (RLT), accounting for tumor microstructure, self-irradiation, crossfire, and bystander effects.

For thoracic cancers, respiratory-induced tumor motion must be accounted for to ensure accurate treatment. While real-time tumor tracking represents the ideal in motion management, existing commercial options face significant hurdles to implementation. This s...

Radiotherapy planning for liver tumours remains challenging due to low tumour conspicuity and respiratory motion. This study explores the conditions under which dynamic contrast enhanced (DCE)-CT can be used to enhance tumour delineation for radiotherapy plan...

Stereotactic body radiotherapy (SBRT) plays a central role in the management of early-stage and oligometastatic lung cancer. Over recent years, there has been significant interest in automating treatment planning through the development of knowledge-based pla...

Radiation-induced lung injury, characterized by chronic inflammation and fibrosis, limits the dose we can give in lung cancer radiotherapy. Drugs that block this response have been shown to protect normal lung tissues from radiation. In this study, we wish to...

Desmoplasia around pancreatic cancer reduces blood perfusion and contrast distribution volume (DV), a biomarker of cell density. This study investigates a low-frequency clinical computed tomography perfusion (CTP) protocol to quantify treatment-induced increa...

Definitive radiotherapy for oropharyngeal cancer (OPC) requires adequate PTV coverage, but the optimal degree of target coverage is unknown. Some protocols require a PTVD95≥95% whereas others require PTVD95≥100% of prescription dose. Prescribing higher PTV do...

To develop and evaluate a custom convolutional neural network (CNN) using baseline 68Ga-DOTATATE PET/CT imaging to predict disease control following 177Lu-DOTATATE therapy in patients with neuroendocrine tumors (NETs).

We introduce a framework to optimize administered radioligand activity by calculating DNA lethal lesions (LLs), balancing maximal tumor control with minimal normal tissue damage.

Cardiac radioablation is one of the most demanding applications in radiation oncology, requiring high-dose conformity and steep dose gradients. Conventional C-arm systems, such as Varian TrueBeam (Varian – a Siemens Healthineers Company, Palo Alto, CA), relia...

Accurately identifying clinically significant prostate cancer (PCa) lesions remains a difficult task. Although tumor characteristics associated with false-negative lesions have been investigated, the potential radiologist search strategy issues underlying mis...

Transrectal ultrasound (TRUS)–guided biopsy remains the most widely used method for diagnosing prostate cancer despite its poor lesion conspicuity. Prostate-specific PET (P-PET) provides improved spatial resolution compared to whole-body PET. However, P-PET l...

Clinical innovation is essential for advancing radiation therapy and is often led by clinically medical physicists. As the clinical and academic landscape evolves, establishing a research portfolio presents challenges and new opportunities for medical physici...

Two key challenges in pharmacokinetic modeling (PKM) of dynamic PET are metabolite contamination of the image-derived arterial input function (AIF) and the presence of these metabolites in tissue time-activity curves (TACs). We propose a method to correct for...

The basal thumb joint is a common site of osteoarthritis (OA) in the hand. Joint inflammation and changes in blood flow regulation are associated with disease progression; however, there is a limited understanding of synovial blood flow changes and the impact...

Ultrasound (US)-guided breast biopsy is widely used due to its accessibility and real-time visualization, but operator dependence can contribute to high false-negative sampling. Magnetic resonance imaging (MRI)-guided biopsy offers high sensitivity but is com...