Author profile
Lawson Health Research Institute
To develop an approach for deriving myocardial perfusion maps directly from multi-phase coronary CT angiography (CTA), eliminating the need for dedicated cardiac CT perfusion (CTP) protocols.
This study develops a CT perfusion (CTP) method for simultaneous lung ventilation and perfusion imaging, overcoming limitations of conventional V/Q scans such as temporal mismatch, low resolution, procedural inefficiency, and qualitative-only evaluation.
To accurately calculate the cellular-level absorbed dose for 225Ac, 177Lu, and 161Tb radioligand therapy (RLT), accounting for tumor microstructure, self-irradiation, crossfire, and bystander effects.
Desmoplasia around pancreatic cancer reduces blood perfusion and contrast distribution volume (DV), a biomarker of cell density. This study investigates a low-frequency clinical computed tomography perfusion (CTP) protocol to quantify treatment-induced increa...
We introduce a framework to optimize administered radioligand activity by calculating DNA lethal lesions (LLs), balancing maximal tumor control with minimal normal tissue damage.
Two key challenges in pharmacokinetic modeling (PKM) of dynamic PET are metabolite contamination of the image-derived arterial input function (AIF) and the presence of these metabolites in tissue time-activity curves (TACs). We propose a method to correct for...