Harbin Institute of Technology

Beam angle optimization (BAO) is a critical component of radiation therapy (RT) treatment planning, particularly for proton therapy, where small variations in beam configuration can substantially affect plan quality. BAO is naturally formulated as a mixed-int...

Proton LATTICE (pLATTICE) therapy delivers spatially heterogeneous dose distributions with high‑dose peaks embedded within low‑dose valleys. Conventional pLATTICE planning typically uses multiple beam angles per peak, making peak localization vulnerable to pr...

FLASH radiotherapy (FLASH-RT) has emerged as a promising technique that delivers radiation at ultra-high dose rates (UHDR), which significantly spares normal tissues while still effectively controlling tumors, referred to as the FLASH effect. In proton FLASH...

Intensity-modulated proton therapy (IMPT) provides superior dose conformity and sparing of healthy tissues compared with photon radiotherapy. Improving delivery efficiency is clinically important for reducing motion-induced uncertainties, enhancing plan robus...