FLASH radiation therapy, which utilizes FLASH effect with ultra-high-dose-rate (UHDR) radiation, has shown promising performance in achieving treatment goals with decreased risks on healthy organs of patients. However, a number of factors, including patient-s...
Author profile
Ya-Nan Zhu
School of Mathematics
For proton spots to be deliverable, the intensity of each spot must either be zero or exceed a specific minimum monitor unit (MMU) threshold, which is a nonconvex problem. This study develops a quantum computing (QC)-based optimization framework to address th...
Beam angle optimization (BAO) is a critical component of radiation therapy (RT) treatment planning, particularly for proton therapy, where small variations in beam configuration can substantially affect plan quality. BAO is naturally formulated as a mixed-int...
Intensity-modulated proton therapy (IMPT) provides superior dose conformity and sparing of healthy tissues compared with photon radiotherapy. Improving delivery efficiency is clinically important for reducing motion-induced uncertainties, enhancing plan robus...