University of Nebraska Medical Center

Ultrasound-guided high-dose-rate (HDR) interstitial prostate brachytherapy is a technically demanding procedure requiring proficiency in imaging, catheter reconstruction, contouring, treatment planning, and quality assurance under time-constrained conditions....

To apply a proton procedure of optimizing spot weight and Ridge Filter (RF) to single-energy carbon pencil beam and evaluate it in a water phantom with a square-shape target in the center (prescription dose 50 Gy).

To develop an optimization procedure of spot weight and ridge filter (RF) dimension for single-energy proton pencil beam and apply it to a water phantom with a square-shape target in the center (prescription dose 50 Gy).

Intravenous (IV) and oral contrast are often utilized during the CT simulation for radiation planning. Overriding contrast prior to planning and dose calculations is often a part of standard workflow. This project investigates the real-world impact the presen...

The radius and spacing of high-dose spheres (HDS) in Lattice Radiotherapy (LRT) used by clinicians varies considerably This study quantifies how changing these parameters impacts dosimetric characteristics (such as peak-to-valley dose ratio (PVDR) and mean do...

Robotic bolus has potential to enhance surface dosimetry by reducing air gaps through adaptive surface contouring and providing immobilization for treatment regions. This study evaluated filler materials for a jamming-style robotic bolus as an initial proof-o...

To mechanistically define the beam parameter space required for FLASH radioprotection, moving beyond Mean Dose Rate (MDR) to identify critical constraints in pulse structure (dose-per-pulse and frequency).

To develop a mechanistic extension of the classical Lethal and Potentially Lethal (LPL) model that explains oxygen-mediated ultra-high dose rate (FLASH) sparing without prescribing dose-rate–dependent radiosensitivity.

In-vivo dosimetry in electron radiotherapy ensures accurate plan delivery and patient safety. In hypofractionated treatments such as Boom-Boom radiation (2 Gy in 2 fractions) for indolent B-cell non-Hodgkin lymphomas, the use of small cutout fields increased...

MC simulations were used to accurately determine the water-equivalent thickness (WET) of the buildup housing, the effective point of measurement (EPOM), and the proton- and chamber-specific factor fQ, the MC-derived component of the beam quality correction fa...

Alopecia from rotational total skin electron therapy (TSET) poses severe psychological challenges for patients with special social needs. Depending on the location of the disease, some patients may be candidates for scalp-sparing TSET. We herein present the c...

This work aims to develop a physics-aware deep learning framework for radiotherapy dose prediction that improves accuracy and clinical efficiency. The proposed Physics-Aware Multimodal UNet (PhysMM-UNet) integrates CT images, fluence maps, organ masks, and mu...

Ultrasound-guided high-dose-rate (UGHDR) brachytherapy for prostate cancer depends on real-time transrectal ultrasound (TRUS) imaging for catheter guidance. However, the limited ability of TRUS to depict critical bony anatomy, such as the pubic arch, poses ch...

Accurate real-time tumor tracking is critical for MRI-guided radiotherapy, where geometric uncertainty can significantly increase dose to surrounding critical organs. Continuous cine-MRI enables motion-adaptive treatment. However, accurate tracking under larg...

To quantify the dosimetric consequences of physiology-composed abdominal motion on pancreatic cancer SBRT.

Existing deep learning-based dose prediction methods primarily learn empirical mappings between anatomy and dose, without modeling beam delivery physics. This gap may limit their robustness and accuracy, especially in heterogeneous regions where dose depositi...