McGill University

To calculate the minimum viable sequencing parameters needed to detect radiation-induced mutations using single-cell whole-genome DNA sequencing.

Occupational exposure during Lutetium-177 (Lu-177) radiopharmaceutical therapy depends on administration technique, shielding configuration, and staff proximity—temporal and spatial. This study quantified extremity and whole-body exposure contributions for va...

The dielectric wall accelerator (DWA) offers a low-cost solution for proton therapy with non-resonant waveguides. Radial waveguides (RWGs) transport electronically-switched nanosecond pulses and produce an accelerating electric field in the beam pipe. Previou...

Our university’s Medical Physics M.Sc. prepares students for Canadian board certification through written and oral assessments. Despite the additional time and effort involved, oral exams remain part of the curriculum due to their perceived educational value....

To validate whether switching from one AI autocontouring software for organ at risk (OAR) segmentation to another is possible seamlessly in a clinical radiation therapy environment by comparing 1) the number of OARs available 2) the quality of OARs 3) the com...

To investigate the feasibility and potential benefits of biologically optimised treatment planning (BiRT) utilizing heterogeneous focal-boost prescriptions based on patient-specific cell density distributions. This study compares conventional high-dose-rate b...

The accurate estimation of patient entrance skin dose (ESD) is an important part of diagnostic radiology quality assurance. ESD is commonly calculated by measuring incident (scatter‑free) air kerma on a PMMA phantom and applying an appropriate backscatter fac...

In head-and-neck (H&N) cancer radiotherapy, using IMRT and VMAT, treatment evaluation relies primarily on dose–volume histograms DVH. While effective for quantifying dose magnitude, DVH discard spatial information that may be critical for understanding toxici...

Clinical notes in oncology are generally free-text documents that often repeat clinical information copied from elsewhere in the patient’s medical record, creating inefficiency and risk of propagation error. Therefore, the primary objective of our research is...

Proton therapy (PT) has demonstrated superior healthy tissue sparing compared to photon radiotherapy for various sites; however, PT systems are expensive, which limits global availability. The dielectric wall accelerator (DWA) is proposed as a low-cost, compa...

To evaluate the feasibility and accuracy of a hyperspectral plastic scintillation detector (PSD) system (Medscint HYPERSCINT QA-200 with PRB-0019 probe)—commonly used for brachytherapy dosimetry—for Gamma Knife (GK) small-field dosimetry, and to quantify dete...

Accurate localization of brachytherapy needles in transrectal ultrasound (TRUS) is essential for high-quality treatment planning, yet remains challenging due to speckle noise, needle shadowing, and variable image quality. This work presents a robust, geometry...

To evaluate the feasibility of a hydrated-electron dosimeter prototype for proton FLASH beams and to characterize its sensitivity and response.

To validate and assess the performance of an AI-assisted tool, CorneliUS, for needle reconstruction in high dose rate (HDR) ultrasound-guided prostate brachytherapy in an independent clinical setting.

To integrate post-radiation DNA repair, post‑repair mutation creation, and whole‑genome sequencing into a Monte Carlo–based simulation pipeline in order to observe and quantify chromosome translocations resulting from radiation‑induced DNA damage.

Head and neck cancer (HNC) patients undergoing radiotherapy often necessitate replanning due to anatomical changes. However, replanning is resource-intensive and typically decided on short notice, causing workflow disruptions and treatment delays. Therefore,...

Clinical centres currently employ institution-specific methods for patient imaging (including imaging protocols and preprocessing methods), register, and store information. This lack of semantic standardization creates significant barriers to cross-institutio...

Monte Carlo (MC) simulations are the gold standard in high dose rate brachytherapy (HDR-BT) dosimetry, offering accurate dose-to-medium calculations beyond the dose-to-water calculations used clinically. However, clinical adoption remains limited by long simu...

To develop and validate a modality-aware cross-modal transformer for joint fusion in relapse-free survival prediction in HPV-associated oropharyngeal cancer (OPSCC), integrating PET/CT imaging and clinical data for risk stratification.

Background: Comparative studies show that at kilovoltage energies, EGSnrc and Geant4 can differ by several percent in ionization chamber response, particularly in small air cavities and steep dose gradients. These discrepancies are primarily attributed to dif...

To perform a root cause analysis (RCA) of LINAC geometric error (LGE) dependency on target distance from isocenter for multitarget radiosurgery (SIMT) treatments and develop efficient and accurate clinical QA workflows

Catheter displacement in multi-fraction HDR-brachytherapy is a recognized yet poorly quantified concern. This study evaluates the magnitude of these deviations and their impact on biologically-equivalent-dose (EQD2) metrics.

To compare the repeatability of quantitative dynamic contrast enhanced (DCE) MRI with the reference region model (RRM) against the conventional Tofts model and to test if it can be improved using the two-step Constrained RRM (CRRM).

This work demonstrated the feasibility of performing in-water dose calculations with Monte Carlo (MC) simulations of the Vektra Electronic Brachytherapy (EB) system (Empyrean, Boca Raton, FL). The Vektra is a novel method of EB, using beam steering and intern...

Therapy Physics

Clinical translation of radiomics is hindered by the computational complexity of the feature extraction process, high-dimensional feature sets, and lack of accessible tools for healthcare professionals. We introduce MEDiml, a new open-source platform designed...

To estimate the impact of heartbeat on the dose distribution in cardiac radioablation (CRA) patients treated with CyberKnife and compare the error in respiratory tracking to cancer patients with a similar protocol.

Hypoxia is a marker of tumours progression and treatment outcomes. This study aims to non-invasively map tumour hypoxia using MR-oximetry in a syngeneic murine model. We evaluate the effect of radiotherapy (RT) and L-carnosine (vascularization modifier) on tu...

Survival models based on whole-slide images (WSIs) often function as "black boxes," hindering clinical adoption despite high accuracy. Clinicians require granular explanations to identify which tissue components drive prognostic risk. We present an agent-base...

Accurate measurement of the arterial input function (AIF) is important for kinetic modelling in dynamic PET but typically requires invasive arterial blood sampling. This study validates a novel quantification framework that leverages anatomical priors and a s...