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Medical Physics Unit, McGill University
To calculate the minimum viable sequencing parameters needed to detect radiation-induced mutations using single-cell whole-genome DNA sequencing.
In head-and-neck (H&N) cancer radiotherapy, using IMRT and VMAT, treatment evaluation relies primarily on dose–volume histograms DVH. While effective for quantifying dose magnitude, DVH discard spatial information that may be critical for understanding toxici...
Clinical notes in oncology are generally free-text documents that often repeat clinical information copied from elsewhere in the patient’s medical record, creating inefficiency and risk of propagation error. Therefore, the primary objective of our research is...
To integrate post-radiation DNA repair, post‑repair mutation creation, and whole‑genome sequencing into a Monte Carlo–based simulation pipeline in order to observe and quantify chromosome translocations resulting from radiation‑induced DNA damage.
Head and neck cancer (HNC) patients undergoing radiotherapy often necessitate replanning due to anatomical changes. However, replanning is resource-intensive and typically decided on short notice, causing workflow disruptions and treatment delays. Therefore,...