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Rank #42 · 21 unique linked submissions.
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Diffusing alpha-emitters Radiation Therapy (Alpha DaRT) requires accurate placement of radioactive sources to ensure full coverage of the Gross Tumor Volume (GTV) while minimizing the required total number and length of implanted sources. We proposed a 3D clo...
Three-dimensional multi-organ segmentation is a critical step in preclinical micro-CT imaging for quantitative analysis and reproducibility of longitudinal studies. However, manual delineation remains time-consuming and prone to inter-operator variability, wh...
In diffusing alpha-emitters radiation therapy (Alpha DaRT), the Diffusion-Leakage (DL) model is used to calculate the spread of radionuclides from unsealed sources implanted in a solid tumor. Various numerical methods for simulating the DL model have been pub...
To achieve accurate dosimetric modeling of Alpha DaRT sources by accounting for the spatial superposition of dose contributions from multiple implanted sources arranged in a regular lattice geometry.
Dose accumulation using deformable image registration (DIR) enables a more accurate evaluation of delivered dose in adaptive radiotherapy, allowing evaluation of discrepancies between planned and delivered treatments. However, different DIR algorithms produce...
Deep inspiration breath-hold (DIBH) can reduce cardiac dose in left-sided breast cancer radiotherapy, but its benefit varies substantially between patients. DIBH is also more resource-intensive than free breathing (FB), increasing treatment time and workflow...
To develop and evaluate a data-driven strategy that optimally combines the full set of virtual monoenergetic images (VMIs) from dual-energy CT to construct an optimal image pair for estimating electron density and proton stopping power ratio (SPR), and to com...
This study aims at addressing key concepts of radiation dosimetry in the presence of a magnetic field as a complement to the AAPM TG-351 reference dosimetry protocol for radiotherapy guided by magnetic resonance imaging (MRgRT).
Accurate dose measurement in ultra-high dose rate (UHDR) electron beams is essential for clinical quality assurance. Plastic scintillation detectors (PSDs) are promising candidates for UHDR dosimetry but must demonstrate radiation hardness and calibration sta...
This study aims to evaluate the effective RBE of recoiled nuclei and their contribution to equivalent dose estimation in Alpha DaRT, whose radiobiological impact remains poorly characterized.
Simulation-free (SimF) workflows for MR-guided radiotherapy demonstrate potential to streamline treatment initiation by eliminating dedicated simulation scans. We evaluated the feasibility of implementing an SimF approach for single fraction liver SBRT on the...
Medical physicists are leading the clinical integration of adaptive radiotherapy (ART), using advanced imaging, automation, and dose recalculation tools to personalize treatments in near real-time. While current implementations primarily adapt to anatomical c...
Therapy Physics
Adaptive radiotherapy (ART) requires accurate daily volumetric imaging, yet cone-beam CT (CBCT) is fundamentally limited by X-ray scatter, leading to degraded contrast, CT number inaccuracy, and reduced reliability of automated segmentation. These limitations...
To quantify the dosimetric impact of transitioning from water-based TG-43 dose evaluations to advanced model-based TG-186 calculations in permanent prostate brachytherapy, and to assess the effects on target coverage, organ-at-risk doses, and the appropriaten...
FLASH radiotherapy, defined by ultra-high dose rates (UHDR; >40 Gy/s), can reduce normal-tissue toxicity while maintaining tumor control, yet reported FLASH effects show substantial variability across experimental and preclinical studies. Dielectric materials...
Robust and quantitative treatment planning remains a critical barrier to reproducible preclinical FLASH radiotherapy (FLASH-RT) research. We developed and validated a Monte Carlo–based treatment planning interface (TPI) for electron FLASH beams, enabling accu...
To compare different dual-energy cone-beam CT (DE-CBCT) configurations for the Varian HyperSight system via relative electron density (ED) and effective atomic number (EAN) quantification, as well as contrast improvement.
Deep learning dose prediction (DP) models rapidly predict radiotherapy dose distributions, addressing critical time constraints in adaptive radiotherapy (ART). Recent patient-specific (PS) approaches fine-tune models on individual initial plans for highly tai...
A microfluidic lab-on-a-chip integrating an I-125 brachytherapy seed has recently been developed for radiobiological irradiation of spheroids. This study investigates a novel seed-through-film geometry suitable to validate the dosimetry of this device in the...
Therapy Physics