Author profile
Département de physique, Université de Montréal
Diffusing alpha-emitters Radiation Therapy (Alpha DaRT) requires accurate placement of radioactive sources to ensure full coverage of the Gross Tumor Volume (GTV) while minimizing the required total number and length of implanted sources. We proposed a 3D clo...
Three-dimensional multi-organ segmentation is a critical step in preclinical micro-CT imaging for quantitative analysis and reproducibility of longitudinal studies. However, manual delineation remains time-consuming and prone to inter-operator variability, wh...
In diffusing alpha-emitters radiation therapy (Alpha DaRT), the Diffusion-Leakage (DL) model is used to calculate the spread of radionuclides from unsealed sources implanted in a solid tumor. Various numerical methods for simulating the DL model have been pub...
To achieve accurate dosimetric modeling of Alpha DaRT sources by accounting for the spatial superposition of dose contributions from multiple implanted sources arranged in a regular lattice geometry.
Calculation of the equivalent dose in Diffusing alpha-emitters Radiation Therapy (Alpha DaRT) depends strongly on the spatial dose distribution and the radiobiological impact of emitted alpha particles [1-3]. Current practice in clinical treatment planning sy...
This study aims to evaluate the effective RBE of recoiled nuclei and their contribution to equivalent dose estimation in Alpha DaRT, whose radiobiological impact remains poorly characterized.
To quantify the dosimetric impact of transitioning from water-based TG-43 dose evaluations to advanced model-based TG-186 calculations in permanent prostate brachytherapy, and to assess the effects on target coverage, organ-at-risk doses, and the appropriaten...
A microfluidic lab-on-a-chip integrating an I-125 brachytherapy seed has recently been developed for radiobiological irradiation of spheroids. This study investigates a novel seed-through-film geometry suitable to validate the dosimetry of this device in the...