Johns Hopkins Medical Institute

Advances in ‘first-principles’ models of radiation response allow, in principle, for accurate mechanism-aware prediction of how biological effectiveness and effective linear quadratic (LQ) parameters change across various experimental and clinical conditions....

Quantitative image-based dosimetry for radiopharmaceutical therapy (RPT) increasingly relies on large, multi-organ mechanistic models of physiologically based pharmacokinetics (PBPK). While PBPK models often fit clinical data well, the extent to which their i...

αRPT is a promising treatment modality that is largely impervious to the mechanisms of resistance associated with chemotherapy, conventional radiotherapy, targeted (pathway-inhibition) therapies, and immunotherapy. Osteosarcoma (OS), which frequently expresse...