Extracting Parsimonious Quantitative Predictors of Biological Effectiveness from ‘First-Principles’ Radiobiology: Application to the Mixed-Quality Problem
Advances in ‘first-principles’ models of radiation response allow, in principle, for accurate mechanism-aware prediction of how biological effectiveness and effective linear quadratic (LQ) parameters change across various experimental and clinical conditions....
Poster Program · Therapy Physics
Identifiability, Effective Dimensionality, and Interpretability In PBPK-Based Alpha Rpt Dosimetry
Quantitative image-based dosimetry for radiopharmaceutical therapy (RPT) increasingly relies on large, multi-organ mechanistic models of physiologically based pharmacokinetics (PBPK). While PBPK models often fit clinical data well, the extent to which their i...
Poster Program · Radiopharmaceuticals, Theranostics, and Nuclear Medicine
Kidney, Blood, and Bone Marrow Dosimetry of 225ac-Hu3F8 Targeted Alpha-Emitter Therapy In a Canine Model
αRPT is a promising treatment modality that is largely impervious to the mechanisms of resistance associated with chemotherapy, conventional radiotherapy, targeted (pathway-inhibition) therapies, and immunotherapy. Osteosarcoma (OS), which frequently expresse...
Proffered Program · Radiopharmaceuticals, Theranostics, and Nuclear Medicine