University Of Iowa

This study aimed to assess three different planning approaches for treating central lung SBRT tumors using GPU Acceleration for optimization and GPUMCD for dose calculation in the Elekta One Planning treatment planning system (v6.2.3, EOP).

GPUMCD, a GPU-accelerated Monte Carlo dose calculation algorithm, was recently released for clinical implementation in the Elekta One Treatment Planning System (v6.2.3, EOP) for c-arm Elekta linear accelerators (linac). The purpose of this work was to validat...

Quantitative SPECT imaging of the alpha-emitters Ac-225 and Pb-212 is fundamentally limited by a low count rate and high-energy photon emissions that produce collimator penetration, septal scatter, and detector backscatter within clinically used photopeak win...

To experimentally quantify the mechanical delivery errors of a pre-clinical Dynamical Collimation System (DCS) prototype for intensity modulated proton therapy (IMPT) and evaluate the dosimetric impact of these errors to the target coverage and organ sparing.

Hyperpolarized Xenon imaging is a recent FDA-approved MRI technique that can measure physiological changes in ventilation, membrane uptake, and red blood cell transfer of gas throughout the lung. The scope of this work is to demonstrate the feasibility of int...

To quantify changes in the lung volume due to irradiation.

Volumetric modulated arc therapy (VMAT) machine parameter optimization (MPO) is a high-dimensional problem traditionally reliant on computationally expensive inverse planning. While machine learning techniques have been developed to aide this process, they ty...

Accurate quantitative assessment in positron emission tomography (PET) is essential for reliable lesion characterization and therapy response evaluation. Quantitative accuracy is conventionally investigated using physical phantoms or numerical simulations; ho...

Accurate real-time tumor tracking is critical for MRI-guided radiotherapy, where geometric uncertainty can significantly increase dose to surrounding critical organs. Continuous cine-MRI enables motion-adaptive treatment. However, accurate tracking under larg...

Clinical Trials Specialty Program

To enable consistent COPD quantification in multi-center studies across energy-integrating (EICT) and photon-counting (PCCT) CT technologies, using a physics-based image harmonization technique.

Radiopharmaceuticals, Theranostics, and Nuclear Medicine

Dose-optimized proton pencil beam scanning (PBS) treatments that are collimated using the Dynamic Collimation System (DCS) have greater dosimetric sparing of healthy tissue compared to uncollimated treatment plans, but differences in linear energy transfer (L...

To develop and evaluate a radiomic phenotyping and multi-lesion aggregation scheme to derive patient-level biomarkers for identifying progressive disease and predicting time-to-progression (TTP) in diffuse large B-cell lymphoma (DLBCL).

Radiopharmaceuticals, Theranostics, and Nuclear Medicine