University Medical Center Utrecht

MR-linacs enable online adaptive radiotherapy, which increases dose conformality and thus potentially improves therapeutic ratios. A recurring drawback with respect to C-arm linacs is the lack of VMAT leading to decreased efficiency. Recently, it was demonstr...

Volumetric-modulated arc therapy (VMAT) plan optimization remains a challenging problem due to its non-convex character and the large dimensionality of the solution space. Commonly, the problem is split in three steps: 1) ideal fluence optimization 2) arc seq...

This study investigates the feasibility of VMAT treatments on the MR-Linac by comparing planned and measured quality and deliverability of investigational VMAT plans with existing clinical IMRT plans to determine whether VMAT can maintain clinically acceptabl...

Computed tomography ventilation imaging (CTVI) allows generating ventilation maps from CT data. CTVI provides spatially resolved information on regional lung function that can support functional avoidance and adaptive treatment strategies, but its current rel...

Dosimetric quality assurance (QA) is essential for treatment validation on the MR-linac. However, many conventional QA approaches are challenging in the presence of a magnetic field. In this study a plastic scintillator multi-point QA dosimeter array designed...

The high modulation and spatial complexity of IMRT/VMAT treatment plans motivates the use of patient-specific quality assurance (QA) to verify accurate dose delivery. This study aims to enhance the interpretability of patient-specific QA by adding spatially a...

Intensity modulated radiotherapy (IMRT) is the current standard delivery technique on MR-linacs. IMRT deliveries cycle between radiating and moving segments, each starting with loading the segment. More complex plans usually contain more radiating segments, i...

Effectiveness of EBRT depends highly on target coverage, which is challenged by inter- and intra-fraction anatomical motion. MR-guided radiotherapy (MRgRT) reduces the need for inter-fraction planning margins, by daily adaptive planning, for which daily recon...

To estimate the impact of heartbeat on the dose distribution in cardiac radioablation (CRA) patients treated with CyberKnife and compare the error in respiratory tracking to cancer patients with a similar protocol.

Ventricular tachycardia (VT) arises when abnormal electrical impulses create rapid, self-sustaining ventricular activation instead of normal sinus rhythms. Stereotactic arrhythmia radioablation (STAR) is increasingly used as salvage treatment in refractory VT...