Mu-Han Lin, PhD

Rectal spacers are widely used in prostate stereotactic ablative radiotherapy (SAbR) to reduce rectal dose; however, their value as a practical, planning-oriented QA tool remains underdefined. Using real-world clinical trial data, this study evaluates whether...

Many foundational studies in our field were conducted using non-diverse populations, leading to biases in findings and the development of protocols that may not serve all patients equitably. Consequently, patients excluded from these research cohorts may expe...

The American Association of Physicists in Medicine has sponsored two summer undergraduate research programs since 2001: the Summer Undergraduate Fellowship Program (SUFP) and the Diversity Recruitment through Education and Mentoring Program (DREAM) programs....

Brachytherapy, as a specialized subfield within radiation oncology, demands rigorous education, hands-on training, and substantial clinical experience. Its technical complexities and the risks associated with treatment delivery underscore the need for standar...

Medical physicists go through several failures in their career path, from student life to clinical or research training to being a staff of faculty. The mistakes/screw ups are learning experience for the individual or their local team but can also be a teachi...

Direct-to-Unit (simulation-omitted) radiotherapy enables treatment planning directly from diagnostic imaging, eliminating CT simulation and supporting same-day treatment for time-sensitive cases. These workflows rely on adaptive radiotherapy (ART) platforms t...

The increasing adoption of MRI-guided online adaptive radiotherapy (oART) has improved treatment personalization but introduced substantial technical complexity and time pressure. Existing QA approaches remain largely manual and retrospective, with limited ab...

Patient coaching on the Elekta Unity MR-Linac is challenged by an enclosed bore that limits direct observation and by high acoustic noise during MR imaging that can reduce comprehension of verbal commands. We developed a synchronized, dual-interface visual co...

Combination radiopharmaceutical therapy (RPT) and external beam radiation therapy (EBRT) is an underexplored strategy that may improve outcomes over either modality alone; however, practical implementation requires a clear understanding of dosimetry and radia...

Simulation-omitted prostate SBRT (SO-PRO) has potential to reduce treatment delays and expand access to care but presents unique challenges for SBRT workflows that require careful management of target and organ-at-risk (OAR) dose. A major barrier is diagnosti...

One major bottleneck in MRI-guided online adaptive radiotherapy is the prolonged treatment process, particularly extended delivery times, partly due to the relatively low dose rate and high prescription doses. Efficient radiation delivery is essential for mai...

CBCT-based online adaptive radiotherapy (CBCT-oART) enables daily plan adaptation but is sensitive to intra-fraction motion during extended adaptive workflows. This study evaluates breath-hold (BH) motion stability and workflow impact using an in-bore surface...

Magnetic resonance (MR)–only radiotherapy planning requires accurate synthetic CT (sCT) generation from images acquired using standard clinical MRI simulation protocols. However, MRI acquisition protocols vary substantially across anatomical sites, and many e...

Online adaptive prostate MR-guided radiotherapy (MRgRT) is time-sensitive, and contouring with structure preparation can require upwards of 15 minutes per fraction. While vendor-TPS provided contours can be useful, performance and consistency vary by site, pr...

Magnetic resonance imaging-guided online adaptive radiotherapy (MRgRT) requires a complex planning process, during which an upstream peer review prior to physician approval plays an essential role in early error detection and supporting safe and efficient onl...

To compare MR-simulation motion emulation with measured respiratory gating performance for ultra-central lung treatments on 1.5T MR-linac and to identify the dominant factors affecting gating efficiency. The study focuses on the role of tracking surrogate sel...

To develop and validate consensus electron density (ED) look-up tables (LUTs) for MR-only radiotherapy planning through multi-institutional collaboration.

MRI–only radiotherapy planning requires accurate synthetic CT (sCT) generation to enable dose calculation and patient positioning without a planning CT in Linac-based treatment delivery settings. While prior studies have demonstrated promising results for ind...

Lattice stereotactic body radiation therapy (Lattice SBRT) delivers spatially fractionated high-dose vertices embedded within a lower-dose tumor base, producing steep dose gradients potentially sensitive to interfractional anatomical change. This study evalua...

to evaluate performance of Elekta Unity 1.5T MR-Linac Comprehensive Motion Management (CMM) system across multiple gating strategies and anatomical sites: gastrointestinal(GI), genitourinary(GU), and thoracic(lung). This work aims to provide a practical refer...

Lung cancer cases frequently involve multiple lesions, and treatment with a single isocenter can introduce geometric uncertainties, particularly due to inter-fraction motion. Online adaptive radiotherapy (ART) offers a strategy to mitigate these effects. This...

Direct-to-treatment radiotherapy eliminates CT simulation and pre-planning, reduces consultation-to-treatment intervals from weeks to hours. This study evaluated the feasibility of an ultra-hypofractionated whole-breast workflow that omits simulation and adva...

Vacuum cradles/bags (VC) combined with head and leg immobilization are commonly used for prostate stereotactic body radiotherapy (SBRT) treatment setup. Removing the VC may offer practical advantages for efficient patient positioning, comfort, and high-qualit...

MRI-based intrafraction motion management is increasingly used during MR-guided adaptive radiotherapy, yet limited data exist on its real-world performance and limitations across disease sites. This study reports institutional experience with Comprehensive Mo...

Brachytherapy demands a high level of precision, and even minor errors can lead to significant consequences and adverse patient outcomes. While reportable medical events are documented in the NRC database and other incident learning systems (e.g. RO-ILS), the...

TBD

Time-resolved volumetric MRI reconstructed from minimal k-space samples is critical for motion-adaptive radiotherapy to capture real-time deformable motion. We propose a Gaussian representation-based one-shot learning framework that models patient anatomy and...

In radiation oncology, phase I clinical trials often test the new capabilities of a treatment machine, a novel radiopharmaceutical drug, or an untested clinical indication of radiation therapy. These trials require significant physics investment of time and e...

Professional

Direct-to-unit (DTU) radiotherapy, which bypasses CT simulation and prospective planning, offers an opportunity to markedly shorten the interval from consultation to treatment and expand access to timely breast cancer care. Building on prior feasibility work,...

Deep learning (DL)-based dose prediction has become an important component of modern radiotherapy treatment planning. However, most existing approaches depend on site-specific models, necessitating separate training for each anatomical site, which limits scal...