Yao Hao, PhD

To perform comprehensive dosimetric validation of a commercially available independent Monte Carlo (MC)-based secondary dose calculation engine for clinical photon radiotherapy.

To develop and validate a novel isocentricity test using continuous axis motion and imaging during beam delivery to characterize three-dimensional isocenter walkout.

To validate an online adaptive radiotherapy (oART) workflow for a C-arm linear accelerator (LINAC) equipped with HyperSight CBCT using Imaging and Radiation Oncology Core (IROC) anthropomorphic phantoms.

To develop a global database of medical physics initiatives in support of a sustainable and equitable collaborative ecosystem that minimizes resource duplication and inefficiencies across stakeholders.

This study investigates the feasibility of using two affordable optical surface–imaging technologies to generate detailed 3D maps of the treatment room and patient surface for detecting and mitigating potential collisions between the proton nozzle and the pat...

In the Phase I clinical trial (NCT05831579), we already performed the palliative spatially fractionated (GRID) proton therapy by using a collimating brass aperture. However, the existence of this brass aperture limits the flexibility of the high dose regions...

A novel, low-cost 3D surface scanning system was developed using a custom modification of the laser-profiling technique. Proof of concept was demonstrated through 3D simulation in Blender 3D software. A real-world prototype was then implemented using a consum...

In proton therapy treatment planning, several free parameters impact both plan quality and delivery time. These include spot and energy layer spacing, MU per spot or layer, and in some systems, utilization of adaptive apertures (AA). Decreasing delivery time...

This study seeks to establish a protocol for intracavitary HDR brachytherapy treatment in a murine cervical cancer model mimicking patient treatment procedure. This procedure includes the use of large-bore simulation CT imaging and clinical treatment planning...

Halide perovskites, particularly CsPbBr3, present an exciting opportunity to overcome these limitations due to their high atomic number, fast charge transport, and exceptional radiation tolerance. While perovskite detectors have shown promise for low-energy x...

To develop and validate a continuous two-dimensional output-factor (OF) model and to identify a measurement strategy that achieves accuracy and efficiency.

To quantitatively evaluate and compare imaging performance of various kV-CBCT systems implemented on modern C-arm and O-ring linear accelerator units.

To compare HyperSight imaging systems between O-ring (Halcyon) and C-arm (TrueBeam) machine, with specific emphasis on the impact of motion in resulting dose calculation.

Independent verification of IROC phantom credentialing results is valuable for institutional quality assurance and confidence in treatment planning system performance. This work aimed to verify the accuracy of a commercially available Monte Carlo (MC) dose al...

Proton plans are often homogenous with minimal hotspots, which may not be ideal for ablative stereotactic body radiation therapy (SBRT). A treatment planning approach for stereotactic body proton therapy (SBPT) is proposed to match the characteristics of phot...

To study the cardiac and respiratory heart motion together. Cardiorespiratory motion management is a significant topic in stereotactic arrhythmia radiotherapy (STAR). Cardiorespiratory motion consists of the heart beating and respiration. Commonly studied sep...

It was critical yet impossible to quantitatively assess the impact of patient-specific cardiorespiratory motion on dose plans for stereotactic arrhythmia radioablation (STAR) treatments. To fill the gap, a fast algorithm, SPM (spatial probability map), was de...

Managing cardiac and respiratory motion is critical for stereotactic arrhythmia radiotherapy (STAR), thoracic, and breast treatments. Breath-hold cardiac 4DCT (c4DCT) is commonly required for assessing cardiac motion, while respiratory 4DCT (r4DCT) is used fo...