Library
39 entries curated across talks and posters.
Independent Monte Carlo (MC) dose calculation of clinical pencil beam scanning (PBS) proton treatment plans requires conversion of beam spot monitor units (MU) into the number of protons transported in MC simulations. This conver...
Mechanistic models can help us understand why hadrons kill cells more effectively than photons. We used ChronoRepair, an agent-based model that tracks individual double-strand breaks (DSB) through detection, repair, and cell-fate...
To evaluate CT-derived longitudinal changes in regional lung function following definitive treatment with photon versus proton radiotherapy in patients with locally advanced non-small cell lung cancer (LA-NSCLC).
Medical physics patient consults are increasingly used to support patient understanding during radiotherapy and yet there is no consensus in the medical physics community as to what communications methods are most effective. We c...
Stark global inequities persist in access to radiological health services, with low- and middle-income countries (LMICs) bearing an increasing cancer burden while facing critical shortages in trained medical physicists and radiat...
Clinical proton dose prescription uses a fixed relative biological effectiveness (RBE) factor of 1.1 despite preclinical and clinical evidence that RBE varies with dose, radiation quality and tissue radiosensitivity, particularly...
External-beam therapy now includes various particles such as photons, protons, carbon ions and recently neutrons in Boron Neutron Capture Therapy (BNCT). Accurate and speedy dose calculational algorithms are intergral to the clin...
Real-time dose verification remains a critical unmet need in radiation therapy. We developed physics-informed AI models for radiacoustic imaging (RAI) to enable quantitative, real-time in vivo dose monitoring for proton therapy....
The accessibility of proton therapy is limited by the size and cost associated with traditional acceleration techniques. The dielectric wall accelerator (DWA) was proposed as a low-cost, compact proton accelerator capable of gene...
Toxicities to organs remain a critical limitation to dose escalation in radiotherapy. Ion radiotherapy reduces the absorbed dose to normal tissue but is characterized by a higher relative biological effectiveness (RBE). Existing...
Proton radiation therapy (PRT) is an effective modality for ocular cancers. Substantial evidence indicates that proton relative biological effectiveness (RBE) increases with linear energy transfer (LET). In vitro DNA double-stran...
To exploit differences in J-coupling evolution of the ≈2 ppm fat allylic protons (neighbor the two ends of the double bond chain) to estimate relative linolenic acid content at 3 T. Oleic (mono-unsaturated), linoleic (di-unsatura...
To develop and evaluate a data-driven strategy that optimally combines the full set of virtual monoenergetic images (VMIs) from dual-energy CT to construct an optimal image pair for estimating electron density and proton stopping...
Proton therapy shielding design typically assumes that protons stop within the patient. However, modern treatment planning optimization strategies may introduce high-energy proton transmission (“shoot-through”) spots that exit th...
Radiotherapy is a standard treatment for lung cancer, yet 40%–50% of patients develop local failure or recurrence, largely due to radioresistance. Proton beams, characterized by the Bragg peak and higher relative biological effec...
Proton pencil beam scanning (PBS) offers excellent dose conformity but remains limited by delivery inefficiency associated with energy layer switching time. A programmable energy modulation filter (PEMF) was developed to enable s...
Proton therapy treatments deliver a prescribed absorbed dose to the patient. This work investigates both energy deposition and the temporal evolution of water radiolysis products at micrometric scales, combining a multi-scale app...
Neon ions (²⁰Ne) offer substantially higher clinically achievable dose-averaged linear energy transfer (LETd) escalation in the target compared to protons or carbon ions. LETd escalation has the potential to enhance biological ef...
Radiotherapy is central in lung cancer treatment, but many tumors are intrinsically radioresistant. A mechanism of radioresistance in lung cancer is mutations in the KEAP1 gene, which is present in a significant number (15-20%) o...
To investigate the optimal wall thickness for a Rexolite beam pipe for a proof-of-concept dielectric wall accelerator (DWA). In a DWA, protons are accelerated by a virtual traveling wave, created by switching electric fields alon...
Proton therapy offers superior therapeutic ratio due to its favorable dose distribution, but accurate dose calculation remains challenging. Current methods rely on either pencil-beam algorithms (fast but inaccurate in heterogeneo...
Ultra-high dose rate (FLASH) proton therapy generates positron-emitting radioisotopes, including C-11, O-15, and F-18, which decay via β⁺ emission. Each annihilation produces a pair of 511 keV photons naturally entangled in momen...
To quantify recovery of damaged plastic scintillators and optical fiber after exposure to ultra-high dose rate (UHDR) protons, in terms of light output and spectral signature.
With the number of proton centers increasing, each facing intermittent downtime or need for renovations. Developing optimal approaches to maintain uninterrupted treatment is essential to preserve clinical outcomes. This study out...