Library
2869 entries curated across talks and posters.
Glioblastoma (GBM) remains a lethal brain cancer with a devastating median survival of about 15 months with the current standard of treatment involving surgery, radiation therapy, and chemotherapy utilizing temozolomide (TMZ). Ra...
To evaluate the longitudinal dosimetric and mechanical performance of the Elekta Harmony LINAC over its first year of clinical use in our center.
Cytogenetic biodosimetry provides a biological measure of radiation-induced DNA damage; however, its application in clinical proton therapy patients remains limited. The purpose of this study was to establish a longitudinal frame...
Couch shift accuracy and image-registration performance are central to MR-guided radiotherapy, yet QA is often interpreted with fixed tolerances alone. This study applied statistical process control (SPC) to derive machine-specif...
HyperArc generally provides steeper dose gradients for multiple brain metastases (mets). For a single brain met, utilizing the VMAT technique based on two-orthogonal Arcs with optimal mNTO is an alternative to HyperArc. The purpo...
To measure the fetal dose delivered to pregnant lung cancer patients using AP/PA fields with different beam divergences for consideration of phantom scatter and different distances from the Linac head for evaluation of head leaka...
Metastatic reactivation—the transition of dormant cancer cells into active, proliferative lesions—drives late cancer recurrence in many survivors. In breast cancer, up to 30% of patients develop distant metastases 5–25 years afte...
To evaluate national structure, capacity, and geographic distribution of Medical Physics education and training in Zimbabwe, and assess alignment between academic output and clinical workforce absorption.
Cone beam CTs at typical kV energies exhibit metal artifacts in IGRT patients with metal prosthetics. MV-CBCT, available on some linacs, reduces artifacts at the expense of soft tissue contrast-to-noise (CNR). As a remedy, we pro...
Target alignment is critical for successful SBRT treatment for spinal oligometastatic disease. While CBCT imaging is standard, in-treatment triggered imaging with dual orthogonal kV imaging for internal target monitoring and surf...
Monte Carlo (MC)-based treatment planning system (TPS; RayStation, RaySearch laboratories) and 3D secondary dose check software (VeriQA RT Montecarlo 3D, PTW) were commissioned and benchmarked against well-established TPS. This s...
This study aimed to determine the dose enhancement factor (DEF) in irradiations using a ¹⁹²Ir brachytherapy source in the presence of different mass concentrations of gold nanoparticles (AuNPs) homogeneously distributed within a...
To quantify the effect of tissue assignment variation on dose distributions for ¹⁰³Pd, ¹²⁵I, and ¹³¹Cs seeds in lung brachytherapy.
Radiation-induced oral mucositis (OM) is a severe complication in head and neck cancer patients, significantly impacting quality of life. While Photobiomodulation (PBM) is a promising non-invasive management strategy, clinical pr...
In diffusing alpha-emitters radiation therapy (Alpha DaRT), the Diffusion-Leakage (DL) model is used to calculate the spread of radionuclides from unsealed sources implanted in a solid tumor. Various numerical methods for simulat...
This study reports on a comprehensive MRI-only intracavitary brachytherapy (MR-ICB) commissioning framework with quantitative isodose-based validation against CT.
MR-only radiotherapy (RT) planning faces workflow challenges that limits its use in routine practice. Currently, clinics rely on manual contouring and/or deep learning based automatic segmentation (DLAS) trained using clinical-sp...
Multi-contrast MRI—including T1-weighted contrast-enhanced (T1-CE), T2-weighted (T2), and T2-FLAIR—is essential for brain radiotherapy planning but increases scan time, patient discomfort, and exposure to gadolinium-based contras...
Accurate survival prediction following radiation therapy for glioma remains challenging due to heterogeneous tumor biology and treatment response. This study proposes a multimodal framework integrating deep radiomic features from...
This study aimed to determine the optimal beam configuration for hybrid SBRT in head and neck cancer by systematically comparing 5, 7, 9, and 11 beam arrangements, with particular emphasis on dosimetric quality, robustness to unc...
Treating multiple oligometastatic lesions typically requires creating separate SBRT plans, resulting in longer treatment time and an increase in planning complexity. In this work we evaluate biology-guided multi-target treatment...
This study investigates whether explicitly learning anatomical information in the image domain, when jointly optimized with dose prediction, can improve the accuracy and robustness of CBCT-based dose synthesis.
Accurate radiotherapy dose prediction largely depends on beam configuration, but most deep learning-based dose prediction models rely on explicit beam Angle input, which is not feasible in the early stages of planning. This study...
In image-guided radiation therapy (IGRT), patient positioning is typically estimated by rigid registration between cone-beam CT (CBCT)–derived digitally reconstructed radiographs (DRRs) and treatment kV X-ray images acquired at t...