To investigate the feasibility and potential benefits of biologically optimised treatment planning (BiRT) utilizing heterogeneous focal-boost prescriptions based on patient-specific cell density distributions. This study compares conventional high-dose-rate b...
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The University of Sydney
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The Russian invasion of Ukraine has significantly disrupted radiation therapy (RT) services, highlighting the urgent need to replace Cobalt-60 machines and modernize infrastructure and training across 43 RT centers. In response, Help Ukraine Group (HUG) and R...
To determine a metabolite profile in menstrual blood that indicates endometriosis. This profile is used to establish quantitative diagnostic standards for endometriosis by analysing the metabolite profiles of 1H NMR spectra of menstrual blood.
Amid ongoing war, Ukraine continues to maintain and modernize radiation therapy (RT) services. Between 2023 and 2025, 24 linacs were installed to replace aging, non-rechargeable cobalt units. While linacs offer clinical advantages, they require stringent dosi...
Stereotactic Arrhythmia Radioablation(STAR) is a non-invasive method to treat cardiac arrhythmias by targeting aberrant cardiac tissue, however accurate dose delivery is challenging, given the proximity of the target to vital cardiac structures and the comple...
While real-time tracking devices have demonstrated benefits in clinical outcomes, their safe and effective implementation requires careful consideration. With errors more likely to result from system-wide flaws than isolated failures a systems engineering-bas...
Cone-beam CT (CBCT) guided bronchoscopy enables precise navigation and sampling of suspicious pulmonary nodules but can be associated with a steep learning curve that limits definitive diagnosis. Existing commercial phantoms are predominantly static and lack...
To demonstrate that dual-energy CBCT (DE-CBCT) on angiography systems can deliver material-specific quantitative imaging and metal artifact reduction at the point of intervention.
The excellent soft-tissue contrast provided by MRI offers improved 3D tumour delineation for radiotherapy beam adaptation on MRI-Linacs. However, long acquisition and reconstruction times pose a barrier to achieving volumetric MRI in real time. Current approa...
During liver radiotherapy, respiratory-induced tumor motion can result in target underdose and increased irradiation of surrounding healthy tissue. Existing real-time image-guided approaches often require specialized equipment or invasive marker implantation...
In interventional radiology, the precise 3D localization of mobile targets, particularly within the thorax, is of utmost importance. While conventional modalities such as Cone Beam CT (CBCT) provide necessary depth information, they are unsuitable for real-ti...
Magnetic resonance imaging (MRI) demonstrates strong potential to enable real-time imaging for dose-guided adaptive radiation therapy (ART). However, real-time ART with MRI is limited by long latencies, requiring temporal prediction to achieve accurate treatm...
Targeting accuracy in stereotactic ablative body radiotherapy (SABR) for hepatocellular carcinoma (HCC) is often hindered by the poor soft-tissue visibility of tumors on standard image-guided radiotherapy using kilovoltage (kV) images. However, ~60% of HCC pa...
Functional imaging of the lung has found multiple clinical applications such as improving detection of chronic obstructive pulmonary disease and improving outcomes in radiation therapy by sparing healthy tissue. CT Ventilation Imaging (CTVI) is a recently app...
Therapy Physics