Covenant Health Proton Center

Cytogenetic biodosimetry provides a biological measure of radiation-induced DNA damage; however, its application in clinical proton therapy patients remains limited. The purpose of this study was to establish a longitudinal framework for assessing chromosomal...

Proton transmission fields, treating through the target rather than stopping spots in the target, have a substantial but largely unrealized clinical potential, offering inherently robust delivery with minimal range uncertainty and faster treatment times. To i...

The purpose of this study is to present a novel quality assurance framework that provides a reproducible gold standard for evaluating 4DCT volume reconstruction performance. This framework establishes a gold standard ITV by providing an independent, quantitat...

Cyberattacks pose a growing threat to the continuity of radiation therapy services. Establishing contingency plans (CPs) is critical for rapid recovery post-cyberattack and for maintaining operational resilience. However, the extent of awareness, perceived im...

Proton therapy shielding design typically assumes that protons stop within the patient. However, modern treatment planning optimization strategies may introduce high-energy proton transmission (“shoot-through”) spots that exit the patient and deposit energy i...

Adaptive radiotherapy (ART) decisions made during quality assurance CT (QACT) review are commonly documented in free‑text clinical notes. Automated classification of these rationales could enable large‑scale workflow and quality‑improvement analysis. However,...

In proton therapy, conventional DVH comparisons may be insensitive to planning changes intended to reduce LET‑associated biological risk in normal tissues, despite clinically observed reductions in toxicity. Dose–LET volume histograms (DLVHs) provide a joint...

Respiratory motion and delivery dynamics can affect delivered dose in scanned proton therapy, particularly for thoracic treatments. Many existing motion-evaluation approaches rely on simplified delivery assumptions or research-only implementations, limiting t...

Multi‑target Winston–Lutz (Multi‑WL) testing supports stereotactic QA for single‑isocenter, multi‑lesion SRS/SBRT. Targeting accuracy was benchmarked across 10 clinical linacs (Varian and Elekta) used by multiple institutions to identify parameters associated...