University of Western Ontario

To accurately calculate the cellular-level absorbed dose for 225Ac, 177Lu, and 161Tb radioligand therapy (RLT), accounting for tumor microstructure, self-irradiation, crossfire, and bystander effects.

We introduce a framework to optimize administered radioligand activity by calculating DNA lethal lesions (LLs), balancing maximal tumor control with minimal normal tissue damage.

We previously developed a system capable of acquiring accurate transrectal 3D micro-ultrasound (mUS) images to allow for visualization and focal treatment of intra-prostatic lesions during prostate brachytherapy. This system made use of a mUS probe with non-s...