Electron beam therapy has been used for treating shallow tumors such as skin cancers and postoperative keloids because of its favorable surface‑dose characteristics and simple clinical workflow. These treatments are often delivered with a single field and vis...
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Medstar Georgetown University Hospital
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Spot-scanning proton arc (SPArc) therapy combines the physical advantages of proton therapy with continuous arc delivery. However, most current SPArc planning approaches assume static beam delivery and do not account for the synchrocyclotron-based proton ther...
This study assessed the impact of machine-specific delivery sequence in quantifying interplay effects for lung stereotactic body radiotherapy (SBRT) between two proton therapy modalities, intensity-modulated proton therapy (IMPT) and spot-scanning proton arc...
Proton head-and-neck (HN) patients often experience target volume changes. Our investigation of daily CBCTs showed the changes from swelling to shrinkage happening usually within one week. Offline adaptation takes about one week to create a replan and thus ve...
Breast patients treated with intensity-modulated proton therapy (IMPT) often experience more severe skin dose toxicity compared to those with photon 3DCRT. Here we quantitatively estimated the LET-dependent RBE (LET-RBE) vs clinically used constant RBE=1.1 fo...
To simulate, using Geant4-DNA, proton radiation induced plasmid DNA fragmentation in the plateau as well as Bragg peak regions in a cell-free, aqueous environment of different free radical scavenger concentrations. Atomic Force Microscopy (AFM) measured DNA f...
ZAP-X is a self-shielded radiosurgery system featuring a compact gyroscopic gantry design with kV imaging for patient setup and tracking. Its well-engineered treatment table and treatment-planning system allow lesions located inferiorly to remain treatable. H...
Supercoiled plasmid DNA is widely used to study radiation-induced DNA damage. High-resolution atomic force microscopy (AFM) measurements of radiation-induced DNA fragment-length distributions have directly provided quantitative insights into radiation effects...