University of Oklahoma Health Sciences Center

To perform a dosimetric comparison of Intensity-Modulated Radiation Therapy (IMRT) plans generated using Varian C-arm linear accelerator (LINAC) and Radixact Helical TomoTherapy (TOMO) for breast cancer patients with highly complex, large target volumes, requ...

To demonstrate that Gamma Knife stereotactic radiotherapy with on-board imaging can be safely utilized for pregnant patients using techniques and resources accessible to medical physicists in non-academic clinical settings.

This study aimed to generate system-specific Percent Depth Dose (PDD) and Tissue‑Air Ratio (TAR) curves using an acrylic slab phantom and custom 3D‑printed ion‑chamber holders.

Real-time dose verification remains a critical unmet need in radiation therapy. We developed physics-informed AI models for radiacoustic imaging (RAI) to enable quantitative, real-time in vivo dose monitoring for proton therapy. Our approach addresses two big...

To develop a 3D dose reconstruction algorithm capable of generating volumetric dose distributions measured with large plastic scintillation detectors irradiated with photon, electron, and proton beams used in radiation therapy.

This study compares the dosimetric treatment plan quality of Lattice Radiation Therapy plans generated on Varian C-arm LINACs (TrueBeam and Edge) and Radixact TomoTherapy.

To quantify the discrepancies that occur when a proton treatment plan is delivered on daily anatomy, following the clinical standard of marker-based registration using daily CT imaging. This study aims to demonstrate the necessity for real-time adaptive repla...

HDR cervical brachytherapy requires continuous anesthesia and coordinated execution across multiple clinical teams, yet most workflows are described only by procedural sequence rather than temporal behavior. This study aims (1) to characterize the time requir...

To verify a simplified analysis of imaging and radiation coordinate agreement across multiple geometric scenarios with thresholds that proportionally consider all independent sources of error.

Proton therapy is an increasingly adopted cancer treatment due to its high dose conformity enabled by the Bragg peak (BP), reducing radiation exposure to surrounding healthy tissue. However, this steep dose gradient makes treatment accuracy highly sensitive t...

Accurate radiotherapy delivery requires precise knowledge of soft-tissue anatomy at the time of treatment, particularly for abdominal targets affected by respiration, peristalsis, and inter-fractional anatomical changes. Current clinical systems provide limit...

While Proton Acoustic (PA) imaging has shown promise for range verification, its application in complex transcranial environments remains under-explored. This study aims to demonstrate the feasibility of in situ 3D dose mapping and localization of pulsed prot...