Louisiana State University

MRI guided Adaptive Radiation Therapy (MRgART) allows for daily plan adaptation to the patient’s anatomy. This is achieved by imaging the patient before each fraction, editing the contours to the new anatomy, and adapting the plan to the new contours. However...

To quantify the impact of daily MR-guided adaptive replanning for prostate SBRT on protocol dose-constraint fulfillment, compared with non-adapted reference SBRT plans recalculated on daily anatomy, using both constraint-level pass/fail classification and the...

This work aims to quantify RF-induced heating and local SAR distributions near passive metallic implants within the Elekta Unity. Given the system operates in First Level Mode (4W/kg wbSAR) and the prevalence of implants in the MR-guided adaptive radiotherapy...

X‑ray dark‑field imaging is sensitive to unresolved microstructure and has strong potential for lung tissue characterization, disease identification, and virtual histology. However, quantitative dark-field CT remains challenging due to uncertainties in the vi...

High-dose-rate interstitial brachytherapy (HDR-IBT) is an essential component of curative treatment for locally advanced cervical cancer (LACC), but it is invasive and resource-intensive. Alternative boost techniques are needed when brachytherapy is not feasi...

To quantify the dosimetric impact of interfractional anatomical changes in Syed-based high-dose-rate (HDR) interstitial brachytherapy for locally advanced cervical cancer by comparing a single-plan (non-adaptive) versus multi-planned adaptive strategy.

To evaluate the motion measurement accuracy of transverse and coronal 3D stack-of-stars MR sequences relative to 4D-CT and physical ground truth, using a phantom undergoing hysteretic and non-hysteretic 3D sinusoidal motion.

Proton therapy’s ability to spare normal tissue generally lowers complications, making it an attractive treatment option for head and neck (HN) cancer. Yet, oral mucositis, one of the most frequent and clinically relevant toxicities, occurs in approximately 6...

To improve immobilization of Gamma Knife patients' heads by limiting pronation motion through dental fixation, thereby enabling shorter treatment times, more accurate dose delivery, and enhanced patient comfort.

Precise, accessible, and patient-conformal in-vivo dosimetry remains a central requirement for assurance of safe radiotherapy delivery, particularly in high-dose-rate Total Skin Electron Therapy (HDR-TSET), where large treatment fields and complex patient geo...

Proton therapy plans are optimized by relating the delivered dose to an equivalent photon dose using the Relative Biological Effectiveness (RBE). Clinically, a constant RBE of 1.1 is assumed, despite evidence that RBE varies along the proton beam path. Accura...

Daily anatomical changes can invalidate the geometric, dosimetric, and biological assumptions of reference treatment plans. Quantitative evidence describing fraction-level deviations across disease sites remains limited, and adaptive workflows are often drive...

Evaluate the precision of CT beam width measurements using a pencil ion-chamber.

Low muscle quantity, defined by computed tomography (CT)-based skeletal muscle index (SMI), is emerging as a predictor of clinical outcomes in patients with HNC. This study aims to evaluate whether CT-defined SMI is associated with all-cause mortality in pati...

Dose prediction models operate in the CT dose domain and require a conventional optimization step to translate the predicted dose into deliverable parameters in beam’s-eye view (BEV). To address the taxing direct aperture optimization (DAO) process, directly...

To identify and characterize how blood flow, activity concentration, geometry, and scatter affect the counting abilities of a prototype device to quantitatively measure PET radiotracer blood input function at the wrist.

Therapy Physics

Failure Mode and Effects Analysis (FMEA) is the standard for proactive risk management in radiation therapy under AAPM TG-100 guidelines, yet traditional implementation can exceed 100 hours per process and shows significant inter-rater variability. This work...

X-ray grating interferometry enables the simultaneous acquisition of attenuation, dark-field, and differential phase-contrast images. Dark-field provides sensitivity to sub-resolution microstructural variations inaccessible to conventional radiography. This c...

Therapeutic electron beams are normally characterized by a percent dose versus depth (PDD) curve. Beam tuning based on PDD features can produce large variations in the resulting energy spectra, potentially leading to premature maintenance requirements. A stud...