University of North Carolina

To quantify the impact of daily MR-guided adaptive replanning for prostate SBRT on protocol dose-constraint fulfillment, compared with non-adapted reference SBRT plans recalculated on daily anatomy, using both constraint-level pass/fail classification and the...

To investigate treatment plan quality of head and neck cancers via tumor control and normal tissue complications probability (TCP and NTCP) objectives in the plan optimization process.

To integrate qualitative assessments from experienced treatment planners with quantitative geometric comparisons to evaluate the clinical utility of a deep learning (DL)-based auto-segmentation tool and establish performance criteria grounded in clinical usab...

To examine whether new recently reported dose volume constraints of bladder and rectum can be satisfied in clinical prostate CyberKnife SBRTs without sacrificing target coverage. Also, to use a normal tissue complication (NTCP) model to determine the expected...

To determine which cardiac substructures are associated with radiation-induced cardiac symptoms following radiotherapy for stage III non-small cell lung cancer (NSCLC), and to estimate the corresponding dose–response relationships using a widely applied norma...

Daily anatomical changes can invalidate the geometric, dosimetric, and biological assumptions of reference treatment plans. Quantitative evidence describing fraction-level deviations across disease sites remains limited, and adaptive workflows are often drive...

For craniospinal irradiation (CSI), VMAT offers superior dose conformality and normal tissue sparing compared to traditional 3D techniques. However, generating these plans is cumbersome. It requires multiple isocenters, optimization of a large number of organ...

Radiation oncology accreditation programs aim to promote safety and quality in radiotherapy using nationally recognized standards. This study evaluates the impact of the ASTRO Accreditation Program for Excellence (APEx) at a single institution across three su...

Biology-guided radiotherapy (BGRT) for non-small cell lung cancer (NSCLC) produces high-frequency per-fraction imaging and delivered dose data that captures evolving normal tissue biology throughout treatment. Current toxicity prediction relies on static, pop...