National Institute of Standards and Technology

Radiopharmaceuticals, Theranostics, and Nuclear Medicine

We present advancements of single-molecule biodosimetry to measure radiation-induced DNA damage from α-emitting 225Ac. These results will be compared to β-emitting radionuclides to assess relative biological effectiveness (RBE) for radionuclide therapies.

To provide AAPM members with a centralized, authoritative, and continuously updated web-based resource for obtaining beam quality conversion factors, kQ, and other data needed to realize absorbed dose measurements using the AAPM TG-51 protocol.

To use ultrasonic methods to measure FLASH-beam dose distributions within irradiated water, thereby to validate ultrasonic phase-shift methods for FLASH dosimetry and, ultimately, to differentiate regions where FLASH thresholds are exceeded.

With advances in Targeted Alpha Therapy (TAT) preclinical and clinical research, the importance for accurate and traceable dosimetry with sub-organ resolution becomes critical. Current limitations in verifying imaging resolution and activity quantification hi...