Harvard Medical School

This study seeks to understand the relationship between bolus thickness and dose coverage for the treatment of post-mastectomy breast cancer patients. With the advent of novel bolus materials and 3D printing, it is possible to use bolus with thicknesses outsi...

To quantify organ-at-risk (OAR) sparing achievable using a hybrid approach combining conventional image-guided radiotherapy (IGRT) with a CT-guided online adaptive radiotherapy (CT-ART) cone-down boost for pelvic malignancies.

To demonstrate feasibility of three-dimensional ultrasound (3DUS) for the detection of oral squamous cell carcinoma (OSCC) and to evaluate its potential as a pre-clinical screening tool.

Limiting jaw position across midline is a common inverse-planning strategy to minimize dose to normal tissue and improve conformality when treating irregular targets. However, jawless linacs lack an analogous, planner-controlled method. In this study, we eval...

Peer review is a core component of quality assurance in radiation oncology. This study evaluated whether physician years of clinical experience were associated with differences in peer review change rates within a standardized, prospective, disease-site–speci...

Present interim dosimetry analysis from a prospective, multi-center study (NCT05953337) comparing the mean absorbed dose (Dmean) derived from nuclear medicine (NM) and CT imaging of liver cancer patients undergoing yttrium-90-radioembolization (90Y-RE) with r...

Phase II and III clinical trials establish standards of care in radiation oncology; however, achieving equivalent clinical outcomes in routine practice depends on the reproducible implementation of trial protocols. We systematically evaluated whether publishe...

Clinical Trials Specialty Program

Clinical innovation is essential for advancing radiation therapy and is often led by clinically medical physicists. As the clinical and academic landscape evolves, establishing a research portfolio presents challenges and new opportunities for medical physici...

To investigate mechanisms of chemoradiation resistance in murine head and neck squamous cell carcinoma using a multiscale framework integrating metabolic imaging (μPET), tissue heterogeneity (μCT), and cellular topology (digital pathology).