National Research Council

Therapy Physics

In kV x-ray dosimetry, experimental spectral data can be used to benchmark Monte Carlo simulations and, if the experimental is suitably constrained, test the underlying interaction cross-section models used. This project aims to acquire accurate kV x-ray spec...

This study investigates the magnitude of systematic uncertainties that arise from ignoring quantum effects in semi-classical Monte Carlo (MC) simulations of low-energy electron transport through biological systems. We focus on microdosimetric quantities often...

The overarching goal is to develop a novel system for microdosimetry integrated with cellular molecular radiation response using Monte Carlo (MC) simulations, Raman spectroscopy (RS), and radiobiological assays. MC simulations of the system and initial invest...

To design and validate a Monte Carlo electronic portal imaging device (EPID) model to reduce the uncertainty in the calibration of EPIDs for in-vivo dosimetry of external beam treatments by consolidating correction factors into a single direct measurement.

To provide AAPM members with a centralized, authoritative, and continuously updated web-based resource for obtaining beam quality conversion factors, kQ, and other data needed to realize absorbed dose measurements using the AAPM TG-51 protocol.

This work applies the TG-51 kQ formalism to energies below Co-60 in determining beam quality conversion factors (kQ) for thimble ionization chambers in HDR brachytherapy. The sensitivity of calculations to source-to-detector distance and phantom size is inves...

Therapy Physics

This session is jointly organized by the Working Group on Radiation Dosimetry and Task Group 359 on FLASH (ultra-high dose rate) radiation dosimetry. The session will begin with an educational review of currently available radiation dosimeters used for both c...

To develop a Raman spectroscopy (RS)-based experimental microdosimetry system capable of read-out of a model system of cells cultured on a radiochromic film (RCF) dosimeter substrate that can measure energy deposited by ionizing radiation within individual ce...

To establish a benchmarked radiochemical framework under conventional irradiation and present preliminary results on extending radiochemical simulations to ultra-high-dose-rate (UHDR) beams. FLASH radiotherapy employs UHDR radiation beams that challenge the a...

Robust and quantitative treatment planning remains a critical barrier to reproducible preclinical FLASH radiotherapy (FLASH-RT) research. We developed and validated a Monte Carlo–based treatment planning interface (TPI) for electron FLASH beams, enabling accu...

To demonstrate, for the first time in a clinical setting, the accuracy of a novel robust, dose-rate independent and self-consistent calorimeter system to accurately determine absorbed dose to water in UHDR beams from a Mobetron irradiator.