Huazhong University of Science and Technology

This study aims to investigate the develop ultra-high-dose-rate (UHDR) proton FLASH spatially-fractionated-radiation-therapy (FLASH-SFRT) irradiations on a compact proton synchrocyclotron for preclinical experiments.

Proton arc therapy (PAT) faces two key challenges: minimizing treatment delivery time and eliminating gantry rotation velocity fluctuations. To address these, this study proposes a novel workflow that enables true dynamic arc delivery.

Spot-scanning proton arc (SPArc) therapy combines the physical advantages of proton therapy with continuous arc delivery. However, most current SPArc planning approaches assume static beam delivery and do not account for the synchrocyclotron-based proton ther...

To evaluate the impact of respiratory motion on dose distribution and spatial modulation in VMAT-based Lattice Spatially Fractionated Radiotherapy(Lattice-SFRT), and to evaluate the stability of peak–valley dose characteristics using four-dimensional(4D) dose...

This study assessed the impact of machine-specific delivery sequence in quantifying interplay effects for lung stereotactic body radiotherapy (SBRT) between two proton therapy modalities, intensity-modulated proton therapy (IMPT) and spot-scanning proton arc...

This study aims to introduce a new SPArc algorithm with a variable tolerance window (SPArc-variable) to further improve plan quality for patients receiving bilateral breast and regional nodal irradiation, by allowing extra energy layers across specific arc tr...

Although the number of proton centers continues to rise worldwide, rapid methods for commissioning and dose verification are still lacking. To evaluate the performance of a GPU-accelerated Monte Carlo (MC) dose computational framework for patient-specific pla...

Proton minibeam radiation therapy (pMBRT) reduces normal tissue toxicity while preserving tumor control through spatial dose fractionation. However, multi-slit collimators (MSCs) substantially increase monitor unit requirements and delivery times, limiting cl...

This study aimed to develop a novel optimization framework for spot-scanning proton arc therapy (SPArc) to simultaneously achieve highly uniform beam delivery time (BDT) across control points, improved delivery efficiency, and optimal dose distribution.

Low-field MRI suffers from intrinsically low SNR, which limits image quality and slows wide clinical adoption. Deep learning–based denoising shows strong promise, yet supervised training requires paired high-quality references that are rarely available for lo...

In this work, we experimentally commissioned proton spatially-fractionated-radiotherapy (pSFRT) clinical treatments on a compact proton synchrocyclotron. This involved an initial assessment of proton small-field dosimetry calculation accuracies with comprehen...