A Novel Approach for Pancreatic Cancer Therapy: Cell-Membrane–Coated Radioactive Gold Nanoparticles
To establish, for the first time, a biomimetic nanobrachytherapy platform using radioactive gold nanoparticles coated with PANC-1 cell membrane m198AuNP. This study evaluates their physicochemical properties, nanoscale dose deposition, and feasibility for sel...
Silas Leonel Pereira Miranda, BScSuleyna Prudente, BScMaria Elisa Chuery Martins Rostelato, PhDSabrina Spigaroli Sgrignoli, BScAngélica Barbezan, PhDPriscila Santos Rodrigues, MSc
Therapy Physics
Evaluation of Ionizing Radiation Effects on Polymeric Materials Fabricated By FDM 3D Printing.
To investigate the effects of ionizing radiation on polymeric materials commonly used in fused deposition modeling (FDM) 3D printing, evaluating structural stability, mechanical behavior, and potential microstructural changes following exposure to different i...
Pedro Amaral Medeiros, BScCarlos Alberto Zeituni, PhDDavid Alexander Urbina Leal, MScIlca Marli Moitinho Amaral Medeiros, PhDAna Catarina Koka de Souza Silva, MScPriscila Santos Rodrigues, MSc
Radiopharmaceuticals, Theranostics, and Nuclear Medicine
Imaging-Based Evaluation of Gold Nanoparticles In MCF-7 Cells for Nanobrachytherapy Applications.
To synthesize gold nanoparticles Au197 and Au198 and to evaluate their interaction with MCF-7 breast cancer cells using imaging techniques based on Raman spectroscopy and CLSM Confocal Microscopy.
Silas Leonel Pereira Miranda, BScLara El Hajj Teodoro, MScPriscila Santos Rodrigues, MScMaria Eduarda Zaganin Rigo, MScMaria Elisa Chuery Martins Rostelato, PhDAna Catarina Souza Silva Koka, MSc
Therapy Physics
Optimization of Iodine-125 Production for Prostate Brachytherapy Considering Iodine-126 Contamination and Irradiation Time
The simultaneous production of iodine-125 (¹²⁵I) and iodine-126 (¹²⁶I) during neutron irradiation directly impacts radionuclidic purity and clinical applicability of brachytherapy seeds. This study evaluated the dependence of ¹²⁵I and ¹²⁶I generation on irrad...
José Agostinho Gonçalves de Medeiros, PhDAna Catarina Souza Silva Koka, MScLucas Verdi Angelocci, PhDLara El Hajj Teodoro, MScDavid Alexander Urbina Leal, MScPriscila Santos Rodrigues, MSc
Therapy Physics
Production and Optimization of Yttrium-90 Citrate Via Neutron Activation for Radiosynovectomy
Radiosynovectomy (RSV) is a minimally invasive therapeutic option for the treatment of chronic synovitis, with yttrium-90 (⁹⁰Y) being particularly suitable for large joints such as the knee. In Brazil, national production of therapeutic radiopharmaceuticals r...
Sabrina Spigaroli Sgrignoli, BScEdson Gonçalves Moreira, PhDAna Catarina Souza Silva Koka, MScSilas Leonel Pereira Miranda, BScPriscila Santos Rodrigues, MScIlca Marli Moitinho Amaral Medeiros, PhD
Therapy Physics
BLUE RIBBON POSTER MULTI-DISCIPLINARY: Enhancing Radionuclide Retention In Phosphorus-32 Plesiobrachytherapy Using Chemically Active Silica–Silicone Composites
To develop and characterize a flexible silica-silicone composite incorporating phosphoric acid-impregnated silica to improve phosphorus-32 immobilization and leachability control for plesiobrachytherapy applications.
Silas Leonel Pereira Miranda, BScMaria Eduarda Zaganin Rigo, MScMaria Elisa Chuery Martins Rostelato, PhDIlca Marli Moitinho Amaral Medeiros, PhDSabrina Spigaroli Sgrignoli, BScDavid Alexander Urbina Leal, MSc
Therapy Physics