University of Michigan

Rectal spacers are widely used in prostate stereotactic ablative radiotherapy (SAbR) to reduce rectal dose; however, their value as a practical, planning-oriented QA tool remains underdefined. Using real-world clinical trial data, this study evaluates whether...

Therapy Physics

Re-irradiation is increasingly used for patients with local recurrence or new tumors adjacent to a previously irradiated site. However, high-level evidence on re-irradiation is scarce, particularly the safety and toxicity from cumulative dose. Moreover, there...

Radiopharmaceuticals, Theranostics, and Nuclear Medicine

Verification of source dwell positions in HDR ring applicators is critical due to variability introduced by source wire slack. Conventional autoradiographic film methods are often limited by setup uncertainties—such as manual stem marking—and typically requir...

The Varian GYN ring applicator exhibits known dwell position dependence on source wire behavior and rotational orientation. For the Bravos HDR afterloader, the vendor recommends repeated periodic verification of ring dwell positions, including following Ir-19...

This study investigated performance assessment metrics that, when applied to artificial intelligence (AI) outputs designed to identify the presence of pneumonia on chest radiographs, best align with the subjective clinical opinion of radiologists.

Increasing international collaboration in radiation oncology highlights the need for standardized nomenclature that is consistent across languages. The AAPM Task Group TG‑263U1 established French and Spanish language sub‑groups in 2021 to support multilingual...

Automated stereotactic radiosurgery (SRS) planning often fails to match the high conformity and complex trade-off logic of expert human dosimetrists. We hypothesized that a reasoning-based AI agent, SAGE (Secure Agent for Generative dose Expertise), could gen...

Non-breathing physiological motions of abdominal organs at risk (OARs) are insufficiently characterized to support understanding of their dosimetric impact and possible need for monitoring. The dynamics of such motions were characterized in this investigation.

As thoracic reirradiation becomes more common in clinical practice, the changes of underlying lung comorbidities due to multiple treatments are relatively unknown. Parametric response mapping (PRM) has shown promise as a method of tracking COPD phenotype chan...

To quantify the dosimetric impact of interfractional anatomical changes in Syed-based high-dose-rate (HDR) interstitial brachytherapy for locally advanced cervical cancer by comparing a single-plan (non-adaptive) versus multi-planned adaptive strategy.

MLC backlash is a linac failure mode that results in MLC positional error that has been demonstrated to not be prevented by the linac’s internal safety systems [1]. This study aims to inform on the clinical significance of MLC positional error due to MLC back...

To evaluate the dosimetric benefit of incorporating MR-based functional dose objectives into liver stereotactic body radiation therapy (SBRT) planning.

Ensuring precise delivery of radiotherapy is paramount, especially in high dose rate settings where small deviations can create large, unplanned doses, jeopardizing patient safety and treatment outcome. Current dosimetry and QA methods operate on signals anal...

For a new course of liver stereotactic body radiation (reirradiation), we apply a normal tissue complication probability(NTCP) model to guide planning and estimate toxicity risk. We assessed the effectiveness of this approach in achieving longer survival and...

Efficacy, feasibility, and safety of extracranial, single-fraction MR-guided adaptive radiotherapy (SMART-1fx) was reported in the SMART ONE trial (NCT04939246). This work evaluates SMART plan quality relative to RTOG-0813 standards for an expanded cohort.

Phase II and III clinical trials establish standards of care in radiation oncology; however, achieving equivalent clinical outcomes in routine practice depends on the reproducible implementation of trial protocols. We systematically evaluated whether publishe...

Therapy Physics

Magnetic Resonance Fingerprinting (MRF) provides quantitative T1/T2 mapping that can support diagnosis, treatment planning, and longitudinal assessment in brain glioma. Clinical time limits necessitate accelerated MRF, which may introduce artifacts and bias....

Therapy Physics

Determine if linguistic differences are present in letters of recommendation (LOR) for applicants to medical physics residency programs (MPRPs).

To develop artificial intelligence (AI) methods with improved repeatability and reproducibility, a recognized need is for large, publicly available, and curated imaging data sets. Notable public repositories of DICOM images exist, including the Medical Image...

Artificial intelligence-based denoising has shown much promise in improving signal-to-noise in medical imaging. Our goal was to optimize Y-90 bremsstrahlung SPECT imaging following transarterial radioembolization (TARE) using a deep learning-based denoising m...

Professional

Pediatric dose from CT remains a concern, and recent evidence from radiotherapy has increased interest in dose to specific cardiac substructures (e.g., the left anterior descending coronary artery). Pediatric whole-body phantoms that contain detailed cardiac...

Accurate survival prediction in head and neck squamous cell carcinoma (HNSCC) is clinically important for risk stratification but remains challenging due to small cohort sizes and the difficulty of integrating high-dimensional PET/CT imaging with low-dimensio...

Professional

Radiopharmaceuticals, Theranostics, and Nuclear Medicine

To develop the first histotripsy system for non-invasive ultrasonic mechanical ablation with simultaneous, co-registered MRI and ultrasound feedback.

Therapy Physics