GRACE Grand Challenge Session: Advancing Total Body, Marrow, and Lymphoid Irradiation Treatment Planning
Description
Total body, marrow, and lymphoid irradiation represent some of the most complex and technically demanding areas in modern radiation therapy. Total body irradiation, in particular, plays a crucial role in the management of certain leukemias and lymphomas, serving as part of the conditioning regimen before stem cell or bone marrow transplantation. Achieving optimal dose coverage while sparing critical organs is essential for improving outcomes and minimizing toxicity for these vulnerable patients. However, treatment planning for these indications remains a niche, often under-explored domain, presenting significant challenges even for experienced practitioners. Recent advances in imaging, planning algorithms, and clinical protocols demand innovative approaches to drive real improvements in patient care. This session, organized by the Working Group on Grand Challenges and Task Group 379, recognizes and celebrates the pioneering spirit of Grace Gwe-Ya Kim, PhD, and brings together leaders and innovators from the radiation oncology community. The session will open with an introduction by a challenge organizer, outlining the motivation, scope, and unique hurdles of the Grand Challenge. The highlight will be presentations from the winner and runner-up teams, who will share their successful methods, novel techniques, and key insights. Attendees will gain valuable perspectives on state-of-the-art strategies—ranging from creative contouring solutions to advanced optimization methods—showcasing the potential to push boundaries and elevate standards in total body, marrow, and lymphoid irradiation treatment planning. This session aims to stimulate dialogue, inspire future collaboration, and foster a community-wide drive for excellence in a field where innovation can directly impact patient outcomes.