Carlos Uribe, PhD

Radiopharmaceuticals, Theranostics, and Nuclear Medicine

Accurate 177Lu SPECT quantification is essential for patient-specific dosimetry in radiopharmaceutical therapies. Monte Carlo (MC) based reconstruction uses comprehensive system modeling to stochastically simulate photon transport and detector interactions, p...

Physiologically based pharmacokinetic (PBPK) models used in radiopharmaceutical therapy (RPT) and theranostic digital twins are rapidly increasing in size and mechanistic detail, often containing tens to hundreds of parameters. While such models fit imaging a...

Radiopharmaceutical therapies (RPTs) effectively treat metastatic castration-resistant prostate cancer, yet injected radioactivities remain empirically prescribed. Although physiologically-based pharmacokinetic (PBPK) and pharmacodynamic (PD) models can separ...

Existing "one-size-fits-all" approaches in PSMA radiopharmaceutical therapies (RPTs) fail to account for critical inter-patient variabilities, risking under- or over-treatment. To address this, we are developing theranostic digital twins (TDTs) for reliable p...

Computational nuclear oncology (CNO) methods are advancing rapidly but often developed in isolated tools and workflows that are difficult to reproduce, compare, and share. This fragmentation limits virtual studies and slows translation of physiologically base...

Lesion tracking establishes correspondence across imaging time points to assess disease evolution and treatment response. Despite registration-, graph-, and AI-based methods across CT, MR, PET, and PET/MR, robust correspondence in whole-body CT remains challe...

Theranostic digital twins (TDTs) are virtual representations of individual patients, that integrate clinical patient history, imaging, and physiologically based pharmacokinetic (PBPK) modeling to simulate radiopharmaceutical therapies (RPTs). Their validation...

At the AAPM 2025 conference, these speakers conducted a 90-minute session titled “Building a Radiopharmaceutical Therapy Program and Expanding to Clinical Trials.” Following the talks and the ten-minute Q&A session, the audience continued to ask questions for...

Quantitative Lu-177 SPECT imaging requires balancing statistical precision with clinically feasible acquisition times. Conventional reconstruction relies on triple-energy-window (TEW) scatter correction and is therefore effectively limited to the 208 keV phot...

Radiopharmaceuticals, Theranostics, and Nuclear Medicine