Carri K. Glide-Hurst, PhD

The spread-out Bragg peak (SOBP) technique uses ridge filters to broaden the depth-dose profile, producing a dose distribution similar to a single-field-uniform(SFU) approach. In contrast, the single-energy pristine Bragg peak(SEPBP) approach relies on range...

Coronary artery (CA) calcifications (CACs) connect upstream cardiovascular risks with downstream radiotherapy planning decisions, yet these powerful imaging biomarkers are underutilized in radiation oncology. We developed and validated an opportunistic screen...

National shortages of clinical medical physicists underscore the need for scalable, hands-on learning opportunities. We sought to pilot a structured radiation oncology observership program that enhances clinical knowledge, builds confidence, supports career p...

To develop an automated framework that determines the number and placement of isocenters and target margins for extracranial stereotactic ablative radiotherapy (SABR) in polymetastatic disease, and evaluate lung dose tradeoffs versus uniform margins.

We report the first clinical implementation integrating a 6D upright treatment chair and a vertical CT system for image-guided proton therapy on a synchrotron-based fixed-beamline. This design aims to improve patient workflow and reduce the facility footprint...

Recent advances in cone-beam CT (CBCT) technology, such as large field of view and advanced iterative reconstruction algorithms, offer potential for using these on-board imagers for adaptive radiation therapy (ART). This study quantitatively characterizes the...

Hypofractionated proton therapy for pancreatic cancer is limited by the proximity of radiosensitive abdominal organs. Single-energy Bragg peak (SEBP) proton delivery enables ultra-high dose-rate (UHDR) irradiation and may facilitate FLASH compatible treatment...

Accurate small‑field dosimetry on MR‑linacs remains challenging due to magnetic‑field–induced dose perturbations and steep dose gradients. In this study, the performance of a newly developed unshielded silicon diode has been evaluated for use in small-field d...

Cardiotoxicity is a devastating complication of cancer treatment. Notably, the heart is complex and dose to cardiac substructures (CS) have been strongly linked to radiation-induced cardiac morbidity. The physicist-led, NIH-funded “THE cARdiac Radiation Thera...

Therapy Physics

Therapy Physics

Respiratory-induced interplay effects in spot-scanning proton therapy can lead to dose degradation for lung cancer patients treated under free-breathing conditions. While motion mitigation techniques such as deep-inspiration breath-hold or abdominal compressi...

Clinical Trials Specialty Program

Adaptive radiation therapy (ART) for proton therapy relies on routine offline CT simulations for updated anatomy. To facilitate online proton ART, we present our high‑fidelity regularized Brownian Bridge (rBBrg) framework to perform deterministic cross-modali...

Upright patient positioners coupled with diagnostic-quality vertical CTs at treatment isocenter introduce significant opportunities for online adaptive particle therapy. However, limited upright data constrains our ability to rigorously test and optimize this...