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Author profile
Constantinos Koumenis, PhD
Department of Radiation Oncology, University of Pennsylvania
High-Throughput Interrogation of the Human Hematopoietic Response to Proton Pbs Flash Radiotherapy Using a Bone Marrow-on-a-Chip Platform
The clinical translation of ultra-high dose rate (FLASH) radiotherapy is hindered by an incomplete understanding of the physical parameter space required to optimize normal tissue sparing. This study utilizes a human bone marrow-on-a-chip (BMoC) platform to m...
Proffered Program · Therapy Physics
AI-Assisted Dose and Dose Rate Optimization for Deliverable Proton Conformal Flash Radiotherapy
Proton conformal FLASH radiotherapy must simultaneously satisfy clinical dosimetric goals and deliver ultra-high-dose-rates under machine constraints. This highly coupled optimization problem is currently addressed through manual trial-and-error, limiting pla...
Poster Program · Therapy Physics
Commissioning of a Proton Conformal Flash Radiotherapy Delivery System for a Head and Neck Patient Clinical Trial
A proton conformal FLASH radiotherapy system was developed to generate spread-out Bragg peaks at tumor targets utilizing beam-modifying devices, consist of conformal energy modulator(CEM), range shifter(RS) and brass aperture(BA). The system delivers scanned...
Poster Program · Therapy Physics
BEST IN PHYSICS (THERAPY): Simulation of Dose-Rate Dependent Mechanisms of Lymphocyte Damage In Proton Flash Radiotherapy
Radiation-induced damage to circulating lymphocytes is increasingly recognized as a critical determinant of both normal tissue toxicity and antitumor immune responses. Differences in radiation delivery time between proton conventional and FLASH dose rates may...
Proffered Program · Therapy Physics